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ASB10 ankyrin repeat and SOCS box containing 10 [ Homo sapiens (human) ]

Gene ID: 136371, updated on 17-Sep-2022

Summary

Official Symbol
ASB10provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 10provided by HGNC
Primary source
HGNC:HGNC:17185
See related
Ensembl:ENSG00000146926 MIM:615054; AllianceGenome:HGNC:17185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLC1F
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]
Expression
Biased expression in heart (RPKM 1.4), prostate (RPKM 0.5) and 1 other tissue See more
Orthologs
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Genomic context

See ASB10 in Genome Data Viewer
Location:
7q36.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151175698..151187792, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152348791..152360884, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150872785..150884879, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 1 Neighboring gene Sharpr-MPRA regulatory region 15220 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene ABCF2-H2BK1 readthrough Neighboring gene H2B.K variant histone 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017016.1 RefSeqGene

    Range
    5583..17135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142459.2NP_001135931.2  ankyrin repeat and SOCS box protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001135931.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The transcript contains an in-frame start site 45 codons upstream from the currently annotated site. The annotated downstream AUG is better conserved and has a strong Kozak signal.
    Source sequence(s)
    AF417920, AK055536
    Consensus CDS
    CCDS47750.2
    UniProtKB/Swiss-Prot
    Q6ZUL6, Q8WXI3
    Related
    ENSP00000391137.2, ENST00000420175.3
    Conserved Domains (4) summary
    cd00204
    Location:148256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:148178
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:117168
    Ank_4; Ankyrin repeats (many copies)
    cl02533
    Location:421439
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. NM_001142460.1NP_001135932.2  ankyrin repeat and SOCS box protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001135932.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. The transcript contains an in-frame start site 45 codons upstream from the currently annotated site. The annotated downstream AUG is better conserved and has a strong Kozak signal.
    Source sequence(s)
    AF417920, AK055536
    Consensus CDS
    CCDS47749.2
    UniProtKB/Swiss-Prot
    Q8WXI3
    UniProtKB/TrEMBL
    A0A090N8I2
    Related
    ENSP00000275838.1, ENST00000275838.5
    Conserved Domains (5) summary
    cd00204
    Location:148256
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:152245
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:117168
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:148178
    ANK; ANK repeat [structural motif]
    cl02533
    Location:383401
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. NM_080871.4NP_543147.2  ankyrin repeat and SOCS box protein 10 isoform 3

    See identical proteins and their annotated locations for NP_543147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF417920, AK055536, AK125565, DA898875
    Consensus CDS
    CCDS5921.2
    UniProtKB/Swiss-Prot
    Q8WXI3
    Related
    ENSP00000367098.3, ENST00000377867.7
    Conserved Domains (5) summary
    cd00204
    Location:133241
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:137230
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:133163
    ANK; ANK repeat [structural motif]
    cl02533
    Location:406424
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    151175698..151187792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    152348791..152360884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)