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CPE carboxypeptidase E [ Homo sapiens (human) ]

Gene ID: 1363, updated on 10-Oct-2019

Summary

Official Symbol
CPEprovided by HGNC
Official Full Name
carboxypeptidase Eprovided by HGNC
Primary source
HGNC:HGNC:2303
See related
Ensembl:ENSG00000109472 MIM:114855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPH
Summary
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Expression
Biased expression in brain (RPKM 491.8), prostate (RPKM 192.3) and 11 other tissues See more
Orthologs

Genomic context

See CPE in Genome Data Viewer
Location:
4q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (165379008..165498547)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (166300097..166419482)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1 Neighboring gene uncharacterized LOC105377519 Neighboring gene microRNA 578 Neighboring gene HADHA pseudogene 1 Neighboring gene uncharacterized LOC105377520 Neighboring gene secretoglobin family 1D member 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Insulin processing, organism-specific biosystem (from REACTOME)
    Insulin processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
    Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
  • Type I diabetes mellitus, conserved biosystem (from KEGG)
    Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxypeptidase activity TAS
Traceable Author Statement
more info
PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurexin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein modification process NAS
Non-traceable Author Statement
more info
PubMed 
insulin processing IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to secretory granule IEA
Inferred from Electronic Annotation
more info
 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carboxypeptidase E
Names
carboxypeptidase H
cobalt-stimulated chromaffin granule carboxypeptidase
enkephalin convertase
epididymis secretory sperm binding protein
insulin granule-associated carboxypeptidase
prohormone-processing carboxypeptidase
NP_001864.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001873.4NP_001864.1  carboxypeptidase E preproprotein

    See identical proteins and their annotated locations for NP_001864.1

    Status: REVIEWED

    Source sequence(s)
    AA683379, AA883804, AC012504, X51405
    Consensus CDS
    CCDS3810.1
    UniProtKB/Swiss-Prot
    P16870
    Related
    ENSP00000386104.4, ENST00000402744.9
    Conserved Domains (2) summary
    cd03865
    Location:49371
    M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup
    cd11308
    Location:375449
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    165379008..165498547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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