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PRSS37 serine protease 37 [ Homo sapiens (human) ]

Gene ID: 136242, updated on 13-Mar-2020

Summary

Official Symbol
PRSS37provided by HGNC
Official Full Name
serine protease 37provided by HGNC
Primary source
HGNC:HGNC:29211
See related
Ensembl:ENSG00000165076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRYX2
Expression
Restricted expression toward testis (RPKM 1.6) See more
Orthologs

Genomic context

See PRSS37 in Genome Data Viewer
Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141836278..141849725, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141536078..141541332, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 3 Neighboring gene myosin light chain 6 pseudogene 4 Neighboring gene olfactory receptor family 9 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 9 subfamily A member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable inactive serine protease 37
Names
Peptidase S1 domain-containing protein LOC136242
probable inactive trypsin-X2
protease, serine 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008270.3NP_001008271.2  probable inactive serine protease 37 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008271.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA628371, AC093638, AK172866, BC137353
    Consensus CDS
    CCDS34764.1
    UniProtKB/Swiss-Prot
    A4D1T9
    Related
    ENSP00000297767.3, ENST00000350549.8
    Conserved Domains (1) summary
    cl21584
    Location:28231
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001171951.1NP_001165422.1  probable inactive serine protease 37 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001165422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA628371, AK172866, BC144605
    UniProtKB/TrEMBL
    B7ZMK3
    Conserved Domains (2) summary
    smart00020
    Location:28227
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:28230
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_001370403.1NP_001357332.1  probable inactive serine protease 37 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093638
    Related
    ENSP00000414461.1, ENST00000438520.1
    Conserved Domains (1) summary
    cl21584
    Location:28231
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141836278..141849725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249946.4XP_005250003.1  probable inactive serine protease 37 isoform X1

    See identical proteins and their annotated locations for XP_005250003.1

    Conserved Domains (2) summary
    smart00020
    Location:28258
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:28261
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_005249947.3XP_005250004.1  probable inactive serine protease 37 isoform X1

    See identical proteins and their annotated locations for XP_005250004.1

    Conserved Domains (2) summary
    smart00020
    Location:28258
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:28261
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_011515792.2XP_011514094.1  probable inactive serine protease 37 isoform X3

    See identical proteins and their annotated locations for XP_011514094.1

    Conserved Domains (1) summary
    cl21584
    Location:2198
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_011515793.2XP_011514095.1  probable inactive serine protease 37 isoform X3

    See identical proteins and their annotated locations for XP_011514095.1

    Conserved Domains (1) summary
    cl21584
    Location:2198
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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