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Ecm1 extracellular matrix protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13601, updated on 9-Mar-2023

Summary

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Official Symbol
Ecm1provided by MGI
Official Full Name
extracellular matrix protein 1provided by MGI
Primary source
MGI:MGI:103060
See related
Ensembl:ENSMUSG00000028108 AllianceGenome:MGI:103060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p85
Summary
Enables interleukin-2 receptor binding activity. Acts upstream of or within several processes, including chondrocyte development; regulation of T cell migration; and regulation of bone mineralization. Located in extracellular space. Is expressed in several structures, including alimentary system; bone; cardiovascular system; skin; and testis. Human ortholog(s) of this gene implicated in lipoid proteinosis. Orthologous to human ECM1 (extracellular matrix protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 290.2), bladder adult (RPKM 142.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ecm1 in Genome Data Viewer
Location:
3 F2.1; 3 40.91 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95641459..95646915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95734147..95739876, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated Mcl1 enhancer cluster Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene ADAMTS-like 4 Neighboring gene microRNA 7014 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene predicted gene, 26361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation. Zhang Y, et al. Proc Natl Acad Sci U S A, 2020 Feb 11. PMID 31980528, Free PMC Article
  2. ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice. Fan W, et al. Gastroenterology, 2019 Nov. PMID 31362006
  3. Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production. He L, et al. Proc Natl Acad Sci U S A, 2018 Aug 21. PMID 30087185, Free PMC Article
  4. Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation. Lorentzen KA, et al. Atherosclerosis, 2016 Jan. PMID 26671518
  5. Stromal protein Ecm1 regulates ureteric bud patterning and branching. Paroly SS, et al. PLoS One, 2013. PMID 24391906, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studied the role of extracellular matrix protein 1 (ECM1) in controlling colonic inflammation through macrophages in inflammatory bowel disease (IBD). Findings show that ECM1 has an important function in promoting M1 macrophage polarization.
    Title: ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation.
  2. ECM1, produced by hepatocytes, inhibits activation of TGFB and its activation of hepatic stellate cells to prevent fibrogenesis in mouse liver.
    Title: ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice.
  3. findings suggest ECM1 is released from infiltrating inflammatory cells, which leads to cardiac fibroblast stimulation and fibrosis in aging and myocardial infarction. ECM1 may be a novel intermediary between inflammation and fibrosis.
    Title: Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.
  4. data identify ECM1 as a soluble protein to promote TFH cell differentiation and antibody production.
    Title: Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.
  5. ECM1 seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP-null mice; ECM1 and progranulin chondrogenic growth factor constitute an interaction network.
    Title: Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.
  6. HA accumulation primes the vasculature for atherosclerosis by crosslinking and reorganizing the extracellular matrix (ECM) and by pushing VSMC differentiation towards a less mature phenotype.
    Title: Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation.
  7. Retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses.
    Title: Stromal protein Ecm1 regulates ureteric bud patterning and branching.
  8. regulates TH2 cell egress from lymph nodes during allergic airway inflammation
    Title: ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables interleukin-2 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chondrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endochondral bone growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
extracellular matrix protein 1
Names
secretory component p85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252653.4 → NP_001239582.1  extracellular matrix protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306
    Consensus CDS
    CCDS57237.1
    UniProtKB/TrEMBL
    F8WI14
    Related
    ENSMUSP00000029753.7, ENSMUST00000029753.14
    Conserved Domains (1) summary
    pfam05782
    Location:21 → 558
    ECM1; Extracellular matrix protein 1 (ECM1)

  2. NM_001355070.3 → NP_001341999.1  extracellular matrix protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306
    Conserved Domains (1) summary
    pfam05782
    Location:21 → 558
    ECM1; Extracellular matrix protein 1 (ECM1)

  3. NM_001409917.1 → NP_001396846.1  extracellular matrix protein 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  4. NM_001409919.1 → NP_001396848.1  extracellular matrix protein 1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  5. NM_001409920.1 → NP_001396849.1  extracellular matrix protein 1 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  6. NM_001409921.1 → NP_001396850.1  extracellular matrix protein 1 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  7. NM_001409922.1 → NP_001396851.1  extracellular matrix protein 1 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  8. NM_001409923.1 → NP_001396852.1  extracellular matrix protein 1 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  9. NM_001409924.1 → NP_001396853.1  extracellular matrix protein 1 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  10. NM_001409925.1 → NP_001396854.1  extracellular matrix protein 1 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  11. NM_001409926.1 → NP_001396855.1  extracellular matrix protein 1 isoform 12 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  12. NM_001409927.1 → NP_001396856.1  extracellular matrix protein 1 isoform 13 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  13. NM_001409928.1 → NP_001396857.1  extracellular matrix protein 1 isoform 14 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  14. NM_001409929.1 → NP_001396858.1  extracellular matrix protein 1 isoform 15 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  15. NM_001409930.1 → NP_001396859.1  extracellular matrix protein 1 isoform 16 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  16. NM_001409931.1 → NP_001396860.1  extracellular matrix protein 1 isoform 17 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  17. NM_001409932.1 → NP_001396861.1  extracellular matrix protein 1 isoform 18 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  18. NM_001409933.1 → NP_001396862.1  extracellular matrix protein 1 isoform 19 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  19. NM_001409935.1 → NP_001396864.1  extracellular matrix protein 1 isoform 20 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  20. NM_001409936.1 → NP_001396865.1  extracellular matrix protein 1 isoform 21 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  21. NM_001409938.1 → NP_001396867.1  extracellular matrix protein 1 isoform 22 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  22. NM_001409939.1 → NP_001396868.1  extracellular matrix protein 1 isoform 23 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  23. NM_001409940.1 → NP_001396869.1  extracellular matrix protein 1 isoform 24 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  24. NM_001409941.1 → NP_001396870.1  extracellular matrix protein 1 isoform 25 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  25. NM_001409942.1 → NP_001396871.1  extracellular matrix protein 1 isoform 26 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  26. NM_001409943.1 → NP_001396872.1  extracellular matrix protein 1 isoform 27 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  27. NM_001409944.1 → NP_001396873.1  extracellular matrix protein 1 isoform 28 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  28. NM_001409945.1 → NP_001396874.1  extracellular matrix protein 1 isoform 29 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  29. NM_001409946.1 → NP_001396875.1  extracellular matrix protein 1 isoform 30 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  30. NM_001409947.1 → NP_001396876.1  extracellular matrix protein 1 isoform 31 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  31. NM_001409948.1 → NP_001396877.1  extracellular matrix protein 1 isoform 32 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  32. NM_001409949.1 → NP_001396878.1  extracellular matrix protein 1 isoform 33 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  33. NM_001409950.1 → NP_001396879.1  extracellular matrix protein 1 isoform 34 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  34. NM_001409951.1 → NP_001396880.1  extracellular matrix protein 1 isoform 35 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  35. NM_001409952.1 → NP_001396881.1  extracellular matrix protein 1 isoform 36 precursor

    Status: VALIDATED

    Source sequence(s)
    MG954306

  36. NM_007899.5 → NP_031925.2  extracellular matrix protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031925.2

    Status: VALIDATED

    Source sequence(s)
    MG954306
    Consensus CDS
    CCDS17619.1
    UniProtKB/Swiss-Prot
    Q3U5Q5, Q61508
    Related
    ENSMUSP00000112665.3, ENSMUST00000117507.10
    Conserved Domains (1) summary
    pfam05782
    Location:21 → 559
    ECM1; Extracellular matrix protein 1 (ECM1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95641459..95646915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252413.2 → XP_030108273.1  extracellular matrix protein 1 isoform X5

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 557
    ECM1; Extracellular matrix protein 1 (ECM1)

  2. XM_006500984.4 → XP_006501047.1  extracellular matrix protein 1 isoform X4

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 575
    ECM1; Extracellular matrix protein 1 (ECM1)

  3. XM_011240009.3 → XP_011238311.1  extracellular matrix protein 1 isoform X3

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 576
    ECM1; Extracellular matrix protein 1 (ECM1)

  4. XM_017319450.3 → XP_017174939.1  extracellular matrix protein 1 isoform X6

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 452
    ECM1; Extracellular matrix protein 1 (ECM1)

  5. XM_017319449.3 → XP_017174938.1  extracellular matrix protein 1 isoform X1

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 577
    ECM1; Extracellular matrix protein 1 (ECM1)

  6. XM_011240008.4 → XP_011238310.1  extracellular matrix protein 1 isoform X2

    Conserved Domains (1) summary
    pfam05782
    Location:21 → 576
    ECM1; Extracellular matrix protein 1 (ECM1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61508.2 GenPept UniProtKB/Swiss-Prot:Q61508

Gene LinkOut

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