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ADORA2B adenosine A2b receptor [ Homo sapiens (human) ]

Gene ID: 136, updated on 21-Jun-2020

Summary

Official Symbol
ADORA2Bprovided by HGNC
Official Full Name
adenosine A2b receptorprovided by HGNC
Primary source
HGNC:HGNC:264
See related
Ensembl:ENSG00000170425 MIM:600446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADORA2
Summary
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues See more
Orthologs

Genomic context

See ADORA2B in Genome Data Viewer
Location:
17p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (15927782..15975896)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15848231..15879210)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371557 Neighboring gene LCR17pA recombination region Neighboring gene SPECC1 pseudogene 1 Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene nuclear receptor corepressor 1 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
excretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chronic inflammatory response to non-antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
relaxation of vascular smooth muscle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000676.2NP_000667.1  adenosine receptor A2b

    See identical proteins and their annotated locations for NP_000667.1

    Status: REVIEWED

    Source sequence(s)
    M97759, X68487
    Consensus CDS
    CCDS11173.1
    UniProtKB/Swiss-Prot
    P29275
    Related
    ENSP00000304501.2, ENST00000304222.2
    Conserved Domains (1) summary
    cd15069
    Location:8301
    7tmA_Adenosine_R_A2B; adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    15927782..15975896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523659.3XP_011521961.1  adenosine receptor A2b isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:6187
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011523661.2XP_011521963.1  adenosine receptor A2b isoform X3

    Conserved Domains (1) summary
    cl21561
    Location:17112
    7tm_4; Olfactory receptor
  3. XM_017024197.2XP_016879686.1  adenosine receptor A2b isoform X1

RNA

  1. XR_001752428.1 RNA Sequence

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