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Ebf2 early B cell factor 2 [ Mus musculus (house mouse) ]

Gene ID: 13592, updated on 17-Jan-2023

Summary

Official Symbol
Ebf2provided by MGI
Official Full Name
early B cell factor 2provided by MGI
Primary source
MGI:MGI:894332
See related
Ensembl:ENSMUSG00000022053 AllianceGenome:MGI:894332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OE-3; EBF-2; Mmot1; O/E-3; D14Ggc1e
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of chromatin binding activity. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb mesenchyme; and sensory organ. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 7.4), CNS E11.5 (RPKM 7.0) and 10 other tissues See more
Orthologs
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Genomic context

See Ebf2 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67470741..67668401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67233292..67430952)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30806 Neighboring gene predicted gene 20675 Neighboring gene predicted gene, 52149 Neighboring gene RIKEN cDNA 4930438E09 gene Neighboring gene predicted gene 6878 Neighboring gene predicted gene 10860 Neighboring gene predicted gene, 38409 Neighboring gene predicted gene, 24981

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor COE2
Names
MET-mesencephalon-olfactory TF1
MET-mesencephalon-olfactory transcription factor 1
Olf-1/EBF-like 3
metencephalon-mesencephalon-olfactory transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276387.1NP_001263316.1  transcription factor COE2

    See identical proteins and their annotated locations for NP_001263316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK053013, AK139262, BB669324, CT010493
    Consensus CDS
    CCDS27228.1
    UniProtKB/Swiss-Prot
    O08792, Q543D5
    UniProtKB/TrEMBL
    A0A6P5QZF6, A0A8C6HJ01
    Related
    ENSMUSP00000135500.2, ENSMUST00000176161.8
    Conserved Domains (3) summary
    cd01175
    Location:253337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
  2. NM_001360202.1NP_001347131.1  transcription factor COE2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC050922, BM932499, CT010493
    Consensus CDS
    CCDS27228.1
    UniProtKB/Swiss-Prot
    Q543D5
    UniProtKB/TrEMBL
    A0A6P5QZF6, A0A8C6HJ01
    Related
    ENSMUSP00000135782.2, ENSMUST00000176029.2
    Conserved Domains (3) summary
    cd01175
    Location:253337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
  3. NM_010095.6NP_034225.1  transcription factor COE2

    See identical proteins and their annotated locations for NP_034225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK053013, AK139262, BB669324, CT010493
    Consensus CDS
    CCDS27228.1
    UniProtKB/Swiss-Prot
    O08792, Q543D5
    UniProtKB/TrEMBL
    A0A6P5QZF6, A0A8C6HJ01
    Related
    ENSMUSP00000022637.8, ENSMUST00000022637.14
    Conserved Domains (3) summary
    cd01175
    Location:253337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    67470741..67668401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)