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E4f1 E4F transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 13560, updated on 21-May-2024

Summary

Official Symbol
E4f1provided by MGI
Official Full Name
E4F transcription factor 1provided by MGI
Primary source
MGI:MGI:109530
See related
Ensembl:ENSMUSG00000024137 AllianceGenome:MGI:109530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p120E4F; phi-AP3
Summary
This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in ovary adult (RPKM 25.6), thymus adult (RPKM 24.6) and 28 other tissues See more
Orthologs
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Genomic context

See E4f1 in Genome Data Viewer
Location:
17 A3.3; 17 12.39 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24662752..24674366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24443778..24455392, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A delta isomerase 1 Neighboring gene deoxyribonuclease 1-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E3189 Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E7497 Neighboring gene phosphoglycolate phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor E4F1
Names
RING-type E3 ubiquitin transferase E4F1
putative E3 ubiquitin-protein ligase E4F1
transcription factor E4F
transcription factor phi AP3
NP_001288713.1
NP_001342637.1
NP_031919.2
XP_036016188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301784.1NP_001288713.1  transcription factor E4F1 isoform 1

    See identical proteins and their annotated locations for NP_001288713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154237, AK033285, BC031757, BC057011, BY310538
    UniProtKB/Swiss-Prot
    Q05BH7, Q3UNJ9, Q62065, Q6IR08, Q6PGI1, Q8CCE9, Q9QY56
    UniProtKB/TrEMBL
    A0A2I3BR50
    Related
    ENSMUSP00000154444.2, ENSMUST00000226941.2
    Conserved Domains (2) summary
    COG5048
    Location:193594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520540
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001355708.1NP_001342637.1  transcription factor E4F1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC154237, BC031757
    UniProtKB/TrEMBL
    A0A2I3BR50
    Conserved Domains (2) summary
    COG5048
    Location:34434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360380
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_007893.4NP_031919.2  transcription factor E4F1 isoform 2

    See identical proteins and their annotated locations for NP_031919.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC154237, AK033285, BC031757, BY310538
    Consensus CDS
    CCDS28481.1
    UniProtKB/TrEMBL
    A0A2I3BR50
    Related
    ENSMUSP00000062344.8, ENSMUST00000056032.9
    Conserved Domains (4) summary
    COG5048
    Location:193593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:559583
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_125990.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154237, AK033285, AK077014, BC031757, BC057011, BY310538
    Related
    ENSMUST00000226754.2
  2. NR_188837.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC154237
  3. NR_188838.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC154237

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24662752..24674366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160295.1XP_036016188.1  transcription factor E4F1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BPE3
    Conserved Domains (3) summary
    sd00017
    Location:195215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:235259
    zf-H2C2_2; Zinc-finger double domain