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E4f1 E4F transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 13560, updated on 12-Aug-2018

Summary

Official Symbol
E4f1provided by MGI
Official Full Name
E4F transcription factor 1provided by MGI
Primary source
MGI:MGI:109530
See related
Ensembl:ENSMUSG00000024137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p120E4F; phi-AP3
Summary
This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in ovary adult (RPKM 25.6), thymus adult (RPKM 24.6) and 28 other tissues See more
Orthologs

Genomic context

See E4f1 in Genome Data Viewer
Location:
17 A3.3; 17 12.39 cM
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24443778..24455430, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24580724..24592256, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A delta isomerase 1 Neighboring gene deoxyribonuclease 1-like 2 Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene phosphoglycolate phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor E4F1
Names
RING-type E3 ubiquitin transferase E4F1
putative E3 ubiquitin-protein ligase E4F1
transcription factor E4F
transcription factor phi AP3
NP_001288713.1
NP_031919.2
XP_011244570.1
XP_011244571.1
XP_017172712.1
XP_017172713.1
XP_017172714.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301784.1NP_001288713.1  transcription factor E4F1 isoform 1

    See identical proteins and their annotated locations for NP_001288713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154237, AK033285, BC031757, BC057011, BY310538
    UniProtKB/Swiss-Prot
    Q8CCE9
    Related
    ENSMUSP00000154444.1, ENSMUST00000226941.1
    Conserved Domains (4) summary
    COG5048
    Location:193594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:560584
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001355708.1NP_001342637.1  transcription factor E4F1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC154237, BC031757
    Conserved Domains (2) summary
    COG5048
    Location:34434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360380
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_007893.4NP_031919.2  transcription factor E4F1 isoform 2

    See identical proteins and their annotated locations for NP_031919.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC154237, AK033285, BC031757, BY310538
    Consensus CDS
    CCDS28481.1
    UniProtKB/Swiss-Prot
    Q8CCE9
    Related
    ENSMUSP00000062344.7, ENSMUST00000056032.8
    Conserved Domains (4) summary
    COG5048
    Location:193593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:559583
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_125990.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the central region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154237, AK033285, AK077014, BC031757, BC057011, BY310538
    Related
    ENSMUST00000226754.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    24443778..24455430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246268.2XP_011244570.1  transcription factor E4F1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CCE9
    Related
    ENSMUSP00000154438.1, ENSMUST00000228882.1
    Conserved Domains (4) summary
    COG5048
    Location:193563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:489509
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:529553
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017317225.1XP_017172714.1  transcription factor E4F1 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:34434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360380
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017317224.1XP_017172713.1  transcription factor E4F1 isoform X3

  4. XM_017317223.1XP_017172712.1  transcription factor E4F1 isoform X2

  5. XM_011246269.2XP_011244571.1  transcription factor E4F1 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:195215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221243
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:235258
    zf-H2C2_2; Zinc-finger double domain
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