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COX15 COX15, cytochrome c oxidase assembly homolog [ Homo sapiens (human) ]

Gene ID: 1355, updated on 3-Jun-2018
Official Symbol
COX15provided by HGNC
Official Full Name
COX15, cytochrome c oxidase assembly homologprovided by HGNC
Primary source
HGNC:HGNC:2263
See related
Ensembl:ENSG00000014919 MIM:603646; Vega:OTTHUMG00000018893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEMCOX2
Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 6.2), kidney (RPKM 6.1) and 25 other tissues See more
Orthologs
See COX15 in Genome Data Viewer
Location:
10q24.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (99694793..99732666, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101455886..101492423, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 3 Neighboring gene uncharacterized LOC105378450 Neighboring gene solute carrier family 25 member 28 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene estrogen receptor binding site associated, antigen, 9 pseudogene 1 Neighboring gene cutC copper transporter Neighboring gene ABCC2 intron CAGE-defined mid-level expression enhancer Neighboring gene Nanog homeobox pseudogene 6 Neighboring gene ATP binding cassette subfamily C member 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular respiration IC
Inferred by Curator
more info
PubMed 
heme a biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme a biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
heme a biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
heme biosynthetic process TAS
Traceable Author Statement
more info
 
mitochondrial electron transport, cytochrome c to oxygen IC
Inferred by Curator
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
proton transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory chain complex IV assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
respiratory chain complex IV assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory gaseous exchange TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytochrome complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
cytochrome c oxidase assembly protein COX15 homolog
Names
COX15 homolog, cytochrome c oxidase assembly protein
cytochrome c oxidase assembly homolog 15
cytochrome c oxidase subunit 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008986.1 RefSeqGene

    Range
    5001..28919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_406

mRNA and Protein(s)

  1. NM_001320974.1NP_001307903.1  cytochrome c oxidase assembly protein COX15 homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL133353, BX537557
    UniProtKB/Swiss-Prot
    Q7KZN9
    Conserved Domains (1) summary
    cl19388
    Location:66367
    COX15-CtaA; Cytochrome oxidase assembly protein
  2. NM_001320975.1NP_001307904.1  cytochrome c oxidase assembly protein COX15 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AI760159, AL133353, BX537557
    UniProtKB/Swiss-Prot
    Q7KZN9
    Conserved Domains (1) summary
    cl19388
    Location:66278
    COX15-CtaA; Cytochrome oxidase assembly protein
  3. NM_001320976.1NP_001307905.1  cytochrome c oxidase assembly protein COX15 homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI760159, AK298864, AL133353, BC078161, BX537557
    UniProtKB/Swiss-Prot
    Q7KZN9
    UniProtKB/TrEMBL
    B4DQM2
    Conserved Domains (1) summary
    pfam02628
    Location:1217
    COX15-CtaA; Cytochrome oxidase assembly protein
  4. NM_004376.6NP_004367.2  cytochrome c oxidase assembly protein COX15 homolog isoform 2

    See identical proteins and their annotated locations for NP_004367.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 3' region, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF044323, AI760159, AL133353, BC078161, BX537557, DB094258
    Consensus CDS
    CCDS7481.1
    UniProtKB/Swiss-Prot
    Q7KZN9
    Related
    ENSP00000359514.5, OTTHUMP00000020264, ENST00000370483.9, OTTHUMT00000049819
    Conserved Domains (1) summary
    cl19388
    Location:66367
    COX15-CtaA; Cytochrome oxidase assembly protein
  5. NM_078470.5NP_510870.1  cytochrome c oxidase assembly protein COX15 homolog isoform 1

    See identical proteins and their annotated locations for NP_510870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI760159, AL133353, BC002382, BC078161, BX537557, DB094258
    Consensus CDS
    CCDS7482.1
    UniProtKB/Swiss-Prot
    Q7KZN9
    Related
    ENSP00000016171.5, OTTHUMP00000020263, ENST00000016171.5, OTTHUMT00000049818
    Conserved Domains (1) summary
    cl19388
    Location:66407
    COX15-CtaA; Cytochrome oxidase assembly protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    99694793..99732666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717634.3XP_006717697.1  cytochrome c oxidase assembly protein COX15 homolog isoform X1

    See identical proteins and their annotated locations for XP_006717697.1

    Conserved Domains (1) summary
    cl19388
    Location:66278
    COX15-CtaA; Cytochrome oxidase assembly protein
  2. XM_011539298.2XP_011537600.1  cytochrome c oxidase assembly protein COX15 homolog isoform X1

    See identical proteins and their annotated locations for XP_011537600.1

    Conserved Domains (1) summary
    cl19388
    Location:66278
    COX15-CtaA; Cytochrome oxidase assembly protein
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