U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HUS1B HUS1 checkpoint clamp component B [ Homo sapiens (human) ]

Gene ID: 135458, updated on 5-Aug-2022

Summary

Official Symbol
HUS1Bprovided by HGNC
Official Full Name
HUS1 checkpoint clamp component Bprovided by HGNC
Primary source
HGNC:HGNC:16485
See related
Ensembl:ENSG00000188996 MIM:609713; AllianceGenome:HGNC:16485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HUS1B in Genome Data Viewer
Location:
6p25.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (655939..657100, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (515149..516310, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (655939..657100, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 22 Neighboring gene interferon regulatory factor 4 Neighboring gene exocyst complex component 2 Neighboring gene MARK2 pseudogene 18 Neighboring gene uncharacterized LOC105374873

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126746, MGC126748

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic DNA integrity checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
checkpoint protein HUS1B
Names
HUS1 checkpoint homolog b
hHUS1B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148959.4NP_683762.2  checkpoint protein HUS1B

    See identical proteins and their annotated locations for NP_683762.2

    Status: REVIEWED

    Source sequence(s)
    AL357054
    Consensus CDS
    CCDS4470.1
    UniProtKB/Swiss-Prot
    Q5T4Z2, Q8NHY5
    Related
    ENSP00000370293.2, ENST00000380907.3
    Conserved Domains (1) summary
    pfam04005
    Location:1278
    Hus1; Hus1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    655939..657100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    515149..516310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)