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PM20D2 peptidase M20 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 135293, updated on 7-Aug-2022

Summary

Official Symbol
PM20D2provided by HGNC
Official Full Name
peptidase M20 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:21408
See related
Ensembl:ENSG00000146281 MIM:615913; AllianceGenome:HGNC:21408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACY1L2
Summary
Enables dipeptidase activity and identical protein binding activity. Acts upstream of or within proteolysis and regulation of cellular protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 11.9), ovary (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

See PM20D2 in Genome Data Viewer
Location:
6q15
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89093940..89165565)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90354711..90374228)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (89855774..89875284)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 336, pseudogene Neighboring gene proline rich nuclear receptor coactivator 1 Neighboring gene serine and arginine rich splicing factor 12 Neighboring gene Sharpr-MPRA regulatory region 5254 Neighboring gene uncharacterized LOC101929004 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho2 Neighboring gene tubulin beta 3 class III pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables para-aminobenzoyl-glutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
NOT is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
xaa-Arg dipeptidase
Names
I(2)-alanyl-lysine dipeptidase
aminoacylase-1-like protein 2
beta-Ala-Lys dipeptidase
beta-alanyl-lysine dipeptidase
NP_001010853.1
XP_005248719.1
XP_011533783.1
XP_016865778.1
XP_047274175.1
XP_047274176.1
XP_047274177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010853.3NP_001010853.1  xaa-Arg dipeptidase

    See identical proteins and their annotated locations for NP_001010853.1

    Status: VALIDATED

    Source sequence(s)
    AA503266, AK302464, AL353135, BC035036
    Consensus CDS
    CCDS34499.1
    UniProtKB/Swiss-Prot
    Q86XD9, Q8IYS1
    Related
    ENSP00000275072.4, ENST00000275072.5
    Conserved Domains (1) summary
    cd05672
    Location:31406
    M20_ACY1L2_like; M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89093940..89165565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418220.1XP_047274176.1  xaa-Arg dipeptidase isoform X3

  2. XM_047418221.1XP_047274177.1  xaa-Arg dipeptidase isoform X3

  3. XM_011535481.4XP_011533783.1  xaa-Arg dipeptidase isoform X3

    See identical proteins and their annotated locations for XP_011533783.1

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  4. XM_005248662.5XP_005248719.1  xaa-Arg dipeptidase isoform X3

    See identical proteins and their annotated locations for XP_005248719.1

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  5. XM_017010289.2XP_016865778.1  xaa-Arg dipeptidase isoform X1

  6. XM_047418219.1XP_047274175.1  xaa-Arg dipeptidase isoform X2

RNA

  1. XR_007059208.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90354711..90374228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)