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PM20D2 peptidase M20 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 135293, updated on 1-Jun-2020

Summary

Official Symbol
PM20D2provided by HGNC
Official Full Name
peptidase M20 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:21408
See related
Ensembl:ENSG00000146281 MIM:615913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACY1L2
Expression
Ubiquitous expression in prostate (RPKM 11.9), ovary (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See PM20D2 in Genome Data Viewer
Location:
6q15
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89094818..89165565)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (89850047..89875288)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 336, pseudogene Neighboring gene proline rich nuclear receptor coactivator 1 Neighboring gene serine and arginine rich splicing factor 12 Neighboring gene Sharpr-MPRA regulatory region 5254 Neighboring gene uncharacterized LOC101929004 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho2 Neighboring gene tubulin beta 3 class III pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT para-aminobenzoyl-glutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NOT folic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
peptidase M20 domain-containing protein 2
Names
I(2)-alanyl-lysine dipeptidase
aminoacylase-1-like protein 2
beta-alanyl-lysine dipeptidase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010853.3NP_001010853.1  peptidase M20 domain-containing protein 2

    See identical proteins and their annotated locations for NP_001010853.1

    Status: VALIDATED

    Source sequence(s)
    AA503266, AK302464, AL353135, BC035036
    Consensus CDS
    CCDS34499.1
    UniProtKB/Swiss-Prot
    Q8IYS1
    Related
    ENSP00000275072.4, ENST00000275072.5
    Conserved Domains (1) summary
    cd05672
    Location:31406
    M20_ACY1L2_like; M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89094818..89165565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535481.3XP_011533783.1  peptidase M20 domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011533783.1

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  2. XM_017010291.1XP_016865780.1  peptidase M20 domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  3. XM_005248662.4XP_005248719.1  peptidase M20 domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005248719.1

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  4. XM_017010289.1XP_016865778.1  peptidase M20 domain-containing protein 2 isoform X1

  5. XM_005248661.2XP_005248718.1  peptidase M20 domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005248718.1

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  6. XM_017010290.1XP_016865779.1  peptidase M20 domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cl14876
    Location:1220
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RNA

  1. XR_001743167.1 RNA Sequence

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