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Slc26a2 solute carrier family 26 (sulfate transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 13521, updated on 8-Feb-2024

Summary

Official Symbol
Slc26a2provided by MGI
Official Full Name
solute carrier family 26 (sulfate transporter), member 2provided by MGI
Primary source
MGI:MGI:892977
See related
Ensembl:ENSMUSG00000034320 AllianceGenome:MGI:892977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dtd; ST-OB
Summary
Predicted to enable anion transmembrane transporter activity. Predicted to be involved in ossification and sulfate transmembrane transport. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study diastrophic dysplasia. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 28.9), large intestine adult (RPKM 11.3) and 13 other tissues See more
Orthologs
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Genomic context

See Slc26a2 in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61329926..61344668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61196854..61211596, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene HMG box domain containing 3 Neighboring gene predicted gene, 26403 Neighboring gene predicted gene, 50614 Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene STARR-seq mESC enhancer starr_44743 Neighboring gene ribosomal protein S2, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_44744 Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 beta Neighboring gene predicted gene, 46627

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables solute:inorganic anion antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sulfate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sulfate transporter
Names
diastrophic dysplasia protein homolog
solute carrier family 26 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007885.2NP_031911.1  sulfate transporter

    See identical proteins and their annotated locations for NP_031911.1

    Status: VALIDATED

    Source sequence(s)
    AC148012, AK052942
    Consensus CDS
    CCDS29282.1
    UniProtKB/Swiss-Prot
    Q543D6, Q62273, Q8R2L9
    Related
    ENSMUSP00000119447.2, ENSMUST00000146409.8
    Conserved Domains (2) summary
    TIGR00815
    Location:94715
    sulP; high affinity sulphate transporter 1
    cl00604
    Location:570707
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61329926..61344668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)