Format

Send to:

Choose Destination

HINT3 histidine triad nucleotide binding protein 3 [ Homo sapiens (human) ]

Gene ID: 135114, updated on 12-Oct-2019

Summary

Official Symbol
HINT3provided by HGNC
Official Full Name
histidine triad nucleotide binding protein 3provided by HGNC
Primary source
HGNC:HGNC:18468
See related
Ensembl:ENSG00000111911 MIM:609998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HINT4
Summary
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 18.9), prostate (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See HINT3 in Genome Data Viewer
Location:
6q22.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (125956770..125980244)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126277861..126301390)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene RN7SK pseudogene 56 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene tRNA methyltransferase 11 homolog Neighboring gene Sharpr-MPRA regulatory region 12057 Neighboring gene uncharacterized LOC101928096

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33126, FLJ99898, MGC22976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
histidine triad nucleotide-binding protein 3
Names
HINT-3
HIT-like protein
NP_612638.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138571.5NP_612638.3  histidine triad nucleotide-binding protein 3

    See identical proteins and their annotated locations for NP_612638.3

    Status: VALIDATED

    Source sequence(s)
    AL035689, AY035387, BC015732, BX647228, CX755653, DA393891, DA997963
    Consensus CDS
    CCDS5133.1
    UniProtKB/Swiss-Prot
    Q9NQE9
    Related
    ENSP00000229633.5, ENST00000229633.7
    Conserved Domains (1) summary
    cd01278
    Location:47150
    aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    125956770..125980244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center