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COX7C cytochrome c oxidase subunit 7C [ Homo sapiens (human) ]

Gene ID: 1350, updated on 5-Jan-2020

Summary

Official Symbol
COX7Cprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 7Cprovided by HGNC
Primary source
HGNC:HGNC:2292
See related
Ensembl:ENSG00000127184 MIM:603774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 507.5), heart (RPKM 430.4) and 25 other tissues See more
Orthologs

Genomic context

See COX7C in Genome Data Viewer
Location:
5q14.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (86617941..86620962)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (85913784..85916583)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NBPF member 22, pseudogene Neighboring gene uncharacterized LOC105379064 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit pseudogene Neighboring gene Sharpr-MPRA regulatory region 5947 Neighboring gene small nucleolar RNA, C/D box 138 Neighboring gene RNA, U6 small nuclear 804, pseudogene Neighboring gene long intergenic non-protein coding RNA 2059

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase subunit VIIc protein (COX7C) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion HDA PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 7C, mitochondrial
Names
cytochrome c oxidase polypeptide VIIc
cytochrome c oxidase subunit VIIc
cytochrome-c oxidase chain VIIc
NP_001858.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001867.3NP_001858.1  cytochrome c oxidase subunit 7C, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001858.1

    Status: REVIEWED

    Source sequence(s)
    AC108110, BC001005
    Consensus CDS
    CCDS4063.1
    UniProtKB/Swiss-Prot
    P15954
    Related
    ENSP00000247655.3, ENST00000247655.4
    Conserved Domains (1) summary
    cd00929
    Location:1762
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    86617941..86620962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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