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COX7C cytochrome c oxidase subunit 7C [ Homo sapiens (human) ]

Gene ID: 1350, updated on 23-Nov-2023


Official Symbol
COX7Cprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 7Cprovided by HGNC
Primary source
See related
Ensembl:ENSG00000127184 MIM:603774; AllianceGenome:HGNC:2292
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Ubiquitous expression in kidney (RPKM 507.5), heart (RPKM 430.4) and 25 other tissues See more
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Genomic context

See COX7C in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (86617941..86620962)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (87100950..87103971)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (85913758..85916779)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NBPF member 22, pseudogene Neighboring gene uncharacterized LOC105379064 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit pseudogene Neighboring gene MPRA-validated peak5329 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22744 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:85913517-85914182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:85914183-85914848 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:85940434-85941080 Neighboring gene small nucleolar RNA, C/D box 138 Neighboring gene Sharpr-MPRA regulatory region 9296 Neighboring gene RNA, U6 small nuclear 804, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:86011842-86012439 Neighboring gene long intergenic non-protein coding RNA 2059

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase subunit VIIc protein (COX7C) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cytochrome c oxidase subunit 7C, mitochondrial
cytochrome c oxidase polypeptide VIIc
cytochrome c oxidase subunit VIIc
cytochrome-c oxidase chain VIIc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001867.3NP_001858.1  cytochrome c oxidase subunit 7C, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001858.1

    Status: REVIEWED

    Source sequence(s)
    AC108110, BC001005
    Consensus CDS
    P15954, Q6NR81
    ENSP00000247655.3, ENST00000247655.4
    Conserved Domains (1) summary
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060929.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)