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Slc26a3 solute carrier family 26, member 3 [ Mus musculus (house mouse) ]

Gene ID: 13487, updated on 27-Nov-2024

Summary

Official Symbol
Slc26a3provided by MGI
Official Full Name
solute carrier family 26, member 3provided by MGI
Primary source
MGI:MGI:107181
See related
Ensembl:ENSMUSG00000001225 AllianceGenome:MGI:107181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dra; 9030623B18Rik; 9130013M11Rik
Summary
This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]
Expression
Biased expression in colon adult (RPKM 52.2), large intestine adult (RPKM 13.2) and 2 other tissues See more
Orthologs
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Genomic context

See Slc26a3 in Genome Data Viewer
Location:
12 A2; 12 13.45 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31483141..31523921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31433142..31473922)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7129 Neighboring gene STARR-seq mESC enhancer starr_31853 Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_31854 Neighboring gene tripartite motif-containing 13 pseudogene Neighboring gene Casitas B-lineage lymphoma-like 1 Neighboring gene predicted gene, 40362 Neighboring gene solute carrier family 26, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

Markers

Clone Names

  • 9030623B18Rik, 9130013M11Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bicarbonate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular pH elevation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm capacitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chloride anion exchanger
Names
down-regulated in adenoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021353.3NP_067328.1  chloride anion exchanger

    See identical proteins and their annotated locations for NP_067328.1

    Status: REVIEWED

    Source sequence(s)
    AK018566, BC139271, CR974423
    Consensus CDS
    CCDS25863.1
    UniProtKB/Swiss-Prot
    B2RTD9, Q9WVC8
    Related
    ENSMUSP00000001254.6, ENSMUST00000001254.6
    Conserved Domains (2) summary
    cd07042
    Location:519705
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:73468
    Sulfate_transp; Sulfate permease family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31483141..31523921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314950.1XP_017170439.1  chloride anion exchanger isoform X1

    UniProtKB/Swiss-Prot
    B2RTD9, Q9WVC8
    Conserved Domains (2) summary
    cd07042
    Location:519705
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:73468
    Sulfate_transp; Sulfate permease family
  2. XM_011243812.1XP_011242114.1  chloride anion exchanger isoform X2

    Conserved Domains (1) summary
    TIGR00815
    Location:3396
    sulP; high affinity sulphate transporter 1