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Dpm1 dolichol-phosphate (beta-D) mannosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 13480, updated on 5-Feb-2023

Summary

Official Symbol
Dpm1provided by MGI
Official Full Name
dolichol-phosphate (beta-D) mannosyltransferase 1provided by MGI
Primary source
MGI:MGI:1330239
See related
Ensembl:ENSMUSG00000078919 AllianceGenome:MGI:1330239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables dolichyl-phosphate beta-D-mannosyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process and dolichol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.1), bladder adult (RPKM 4.7) and 28 other tissues See more
Orthologs
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Genomic context

See Dpm1 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168050968..168072299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168209048..168230379, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54130 Neighboring gene predicted gene 20716 Neighboring gene activity-dependent neuroprotective protein Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Gm20716

Readthrough gene: Gm20716, Included gene: Adnp

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dolichol-phosphate mannosyltransferase subunit 1
Names
DPM synthase subunit 1
MPD synthase
dolichol-phosphate mannose synthase subunit 1
dolichyl-phosphate beta-D-mannosyltransferase subunit 1
mannose-P-dolichol synthase subunit 1
NP_001297013.1
NP_034202.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310084.1NP_001297013.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK004834, BF019794, BM941163, BX005039
    UniProtKB/Swiss-Prot
    O70152
    Conserved Domains (2) summary
    cd06442
    Location:29233
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:21237
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
  2. NM_010072.4NP_034202.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_034202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005268, BM941163, BX005039
    Consensus CDS
    CCDS17109.1
    UniProtKB/Swiss-Prot
    O70152, Q9D829
    UniProtKB/TrEMBL
    A0A8C6N5U3
    Related
    ENSMUSP00000118776.2, ENSMUST00000154111.8
    Conserved Domains (2) summary
    cd06442
    Location:29256
    DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
    PLN02726
    Location:21260
    PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168050968..168072299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)