U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 13478, updated on 8-Nov-2022

Summary

Official Symbol
Dpagt1provided by MGI
Official Full Name
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by MGI
Primary source
MGI:MGI:1196396
See related
Ensembl:ENSMUSG00000032123 AllianceGenome:MGI:1196396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPT; G1PT; Gnpta; Dpagt2
Summary
Enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; dolichol metabolic process; and dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 30.3), ovary adult (RPKM 28.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dpagt1 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44237314..44247374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44325857..44333895)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene H2A.X variant histone Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11, CORVET/HOPS core subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Names
N-acetylglucosamine-1-phosphate transferase
UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2
NP_001351393.1
NP_031901.2
XP_006510054.1
XP_006510055.1
XP_006510058.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364464.1NP_001351393.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK008246, BM211613, BM899494, CN665943
    UniProtKB/TrEMBL
    Q9CPT1
    Conserved Domains (1) summary
    cd06855
    Location:1210
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
  2. NM_007875.3NP_031901.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1

    See identical proteins and their annotated locations for NP_031901.2

    Status: VALIDATED

    Source sequence(s)
    AC122428, AC124577
    Consensus CDS
    CCDS23104.1
    UniProtKB/Swiss-Prot
    P42867, Q921W5
    Related
    ENSMUSP00000056282.4, ENSMUST00000054708.5
    Conserved Domains (1) summary
    cd06855
    Location:31319
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44237314..44247374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509991.2XP_006510054.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

    Conserved Domains (1) summary
    cd06855
    Location:3286
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
  2. XM_006509992.3XP_006510055.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

    Conserved Domains (1) summary
    cd06855
    Location:35264
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
  3. XM_006509995.3XP_006510058.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

    See identical proteins and their annotated locations for XP_006510058.1

    UniProtKB/TrEMBL
    Q9CPT1
    Conserved Domains (1) summary
    cd06855
    Location:1210
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...