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IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 134728, updated on 7-Jun-2020

Summary

Official Symbol
IRAK1BP1provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17368
See related
Ensembl:ENSG00000146243 MIM:615375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP70; SIMPL
Expression
Ubiquitous expression in testis (RPKM 2.2), thyroid (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See IRAK1BP1 in Genome Data Viewer
Location:
6q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (78867486..78979411)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (79577261..79714545)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 10524 Neighboring gene uncharacterized LOC107986613 Neighboring gene tRNA-Phe (anticodon GAA) 8-1 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene nucleoporin 155kDa pseudogene Neighboring gene HMGN3 antisense RNA 1 Neighboring gene high mobility group nucleosomal binding domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of interleukin-1 receptor-associated kinase 1 binding protein 1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39542, MGC138458, MGC138460, 4921528N06Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 1-binding protein 1
Names
ActA binding protein 3
IRAK1-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010844.4NP_001010844.1  interleukin-1 receptor-associated kinase 1-binding protein 1

    See identical proteins and their annotated locations for NP_001010844.1

    Status: VALIDATED

    Source sequence(s)
    AL450327, BC112253, CB321683
    Consensus CDS
    CCDS34488.1
    UniProtKB/Swiss-Prot
    Q5VVH5
    Related
    ENSP00000358956.1, ENST00000369940.7
    Conserved Domains (1) summary
    pfam04402
    Location:56197
    SIMPL; Protein of unknown function (DUF541)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    78867486..78979411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535448.2XP_011533750.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X3

    Conserved Domains (1) summary
    pfam04402
    Location:56112
    SIMPL; Protein of unknown function (DUF541)
  2. XM_017010265.1XP_016865754.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X4

  3. XM_006715336.3XP_006715399.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04402
    Location:56197
    SIMPL; Protein of unknown function (DUF541)
  4. XM_011535447.1XP_011533749.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam04402
    Location:56197
    SIMPL; Protein of unknown function (DUF541)

RNA

  1. XR_001743162.1 RNA Sequence

  2. XR_942279.2 RNA Sequence

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