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ACOT12 acyl-CoA thioesterase 12 [ Homo sapiens (human) ]

Gene ID: 134526, updated on 21-Dec-2019

Summary

Official Symbol
ACOT12provided by HGNC
Official Full Name
acyl-CoA thioesterase 12provided by HGNC
Primary source
HGNC:HGNC:24436
See related
Ensembl:ENSG00000172497 MIM:614315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cach; THEAL; CACH-1; STARD15
Expression
Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6) See more
Orthologs

Genomic context

See ACOT12 in Genome Data Viewer
Location:
5q14.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (81309045..81394174, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (80625731..80689988, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986359 Neighboring gene Ras protein specific guanine nucleotide releasing factor 2 Neighboring gene CKMT2 antisense RNA 1 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene single stranded DNA binding protein 2 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2009

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acetyl-coenzyme A thioesterase
Names
START domain-containing protein 15
StAR-related lipid transfer (START) domain containing 15
acyl-CoA thioester hydrolase 12
acyl-coenzyme A thioesterase 12
cytoplasmic acetyl-CoA hydrolase 1
cytosolic acetyl-CoA hydrolase
hCACH-1
NP_570123.1
XP_006714594.1
XP_006714595.1
XP_016864534.1
XP_016864535.1
XP_016864536.1
XP_016864537.1
XP_024310134.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130767.3NP_570123.1  acetyl-coenzyme A thioesterase

    See identical proteins and their annotated locations for NP_570123.1

    Status: VALIDATED

    Source sequence(s)
    AB078619, AC008411, AK122960, BC089437
    Consensus CDS
    CCDS4055.1
    UniProtKB/Swiss-Prot
    Q8WYK0
    Related
    ENSP00000303246.3, ENST00000307624.8
    Conserved Domains (2) summary
    cd08914
    Location:311546
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    81309045..81394174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009047.1XP_016864536.1  acetyl-coenzyme A thioesterase isoform X3

  2. XM_017009046.1XP_016864535.1  acetyl-coenzyme A thioesterase isoform X2

  3. XM_017009045.1XP_016864534.1  acetyl-coenzyme A thioesterase isoform X1

  4. XM_024454366.1XP_024310134.1  acetyl-coenzyme A thioesterase isoform X5

    Conserved Domains (3) summary
    cd08914
    Location:264499
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    PLN02647
    Location:39204
    PLN02647; acyl-CoA thioesterase
    cd03442
    Location:134258
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  5. XM_017009048.1XP_016864537.1  acetyl-coenzyme A thioesterase isoform X7

  6. XM_006714531.2XP_006714594.1  acetyl-coenzyme A thioesterase isoform X4

    Conserved Domains (2) summary
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    cl14643
    Location:311518
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  7. XM_006714532.3XP_006714595.1  acetyl-coenzyme A thioesterase isoform X6

    Conserved Domains (2) summary
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    cl14643
    Location:311377
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
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