U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACOT12 acyl-CoA thioesterase 12 [ Homo sapiens (human) ]

Gene ID: 134526, updated on 19-Sep-2024

Summary

Official Symbol
ACOT12provided by HGNC
Official Full Name
acyl-CoA thioesterase 12provided by HGNC
Primary source
HGNC:HGNC:24436
See related
Ensembl:ENSG00000172497 MIM:614315; AllianceGenome:HGNC:24436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cach; THEAL; CACH-1; STARD15
Summary
Enables identical protein binding activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within acetyl-CoA metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ACOT12 in Genome Data Viewer
Location:
5q14.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (81308609..81394134, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (81793197..81878724, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (80625815..80689953, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Ras protein specific guanine nucleotide releasing factor 2 Neighboring gene uncharacterized LOC124901017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22730 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:80564272-80565471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80565548-80566100 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80566101-80566651 Neighboring gene CKMT2 antisense RNA 1 Neighboring gene MPRA-validated peak5313 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80597135-80597924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:80597925-80598714 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:80728863-80729548 Neighboring gene NANOG hESC enhancer GRCh37_chr5:80746651-80747152 Neighboring gene single stranded DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16141 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:80983594-80984094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16146 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2009 Neighboring gene CRISPRi-validated cis-regulatory element chr5.2010 Neighboring gene uncharacterized LOC107986384

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in acyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
acetyl-coenzyme A thioesterase
Names
START domain-containing protein 15
StAR-related lipid transfer (START) domain containing 15
acyl-CoA thioester hydrolase 12
acyl-coenzyme A thioesterase 12
cytoplasmic acetyl-CoA hydrolase 1
cytosolic acetyl-CoA hydrolase
hCACH-1
NP_570123.1
XP_006714595.1
XP_016864534.1
XP_016864535.1
XP_016864536.1
XP_016864537.1
XP_054207614.1
XP_054207615.1
XP_054207616.1
XP_054207617.1
XP_054207618.1
XP_054207619.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130767.3NP_570123.1  acetyl-coenzyme A thioesterase

    See identical proteins and their annotated locations for NP_570123.1

    Status: VALIDATED

    Source sequence(s)
    AB078619, AC008411, AK122960, BC089437
    Consensus CDS
    CCDS4055.1
    UniProtKB/Swiss-Prot
    B3KVK9, Q5FWE9, Q8WYK0
    Related
    ENSP00000303246.3, ENST00000307624.8
    Conserved Domains (2) summary
    cd08914
    Location:311546
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    81308609..81394134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009047.2XP_016864536.1  acetyl-coenzyme A thioesterase isoform X3

    Conserved Domains (2) summary
    cd08914
    Location:277512
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    cd03442
    Location:147271
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. XM_017009046.2XP_016864535.1  acetyl-coenzyme A thioesterase isoform X2

    Conserved Domains (2) summary
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    cl14643
    Location:311518
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. XM_017009045.2XP_016864534.1  acetyl-coenzyme A thioesterase isoform X1

    Conserved Domains (2) summary
    cd08914
    Location:311546
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  4. XM_017009048.2XP_016864537.1  acetyl-coenzyme A thioesterase isoform X5

    Conserved Domains (2) summary
    cd08914
    Location:106341
    START_STARD15-like; Lipid-binding START domain of mammalian STARD15 and related proteins
    cd03442
    Location:1100
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  5. XM_006714532.3XP_006714595.1  acetyl-coenzyme A thioesterase isoform X4

    Conserved Domains (2) summary
    cd03442
    Location:3115
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    cl14643
    Location:311377
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    81793197..81878724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351641.1XP_054207616.1  acetyl-coenzyme A thioesterase isoform X3

  2. XM_054351640.1XP_054207615.1  acetyl-coenzyme A thioesterase isoform X2

  3. XM_054351639.1XP_054207614.1  acetyl-coenzyme A thioesterase isoform X1

  4. XM_054351642.1XP_054207617.1  acetyl-coenzyme A thioesterase isoform X6

  5. XM_054351644.1XP_054207619.1  acetyl-coenzyme A thioesterase isoform X5

  6. XM_054351643.1XP_054207618.1  acetyl-coenzyme A thioesterase isoform X4