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COX6C cytochrome c oxidase subunit 6C [ Homo sapiens (human) ]

Gene ID: 1345, updated on 5-Jan-2020

Summary

Official Symbol
COX6Cprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 6Cprovided by HGNC
Primary source
HGNC:HGNC:2285
See related
Ensembl:ENSG00000164919 MIM:124090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in heart (RPKM 104.1), colon (RPKM 92.2) and 25 other tissues See more
Orthologs

Genomic context

See COX6C in Genome Data Viewer
Location:
8q22.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (99877865..99893707, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (100890223..100906242, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog B Neighboring gene VISTA enhancer hs909 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 77B Neighboring gene regulator of G protein signaling 22 Neighboring gene F-box protein 43

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit 6C
Names
cytochrome c oxidase polypeptide VIc
cytochrome c oxidase subunit VIc preprotein
epididymis secretory sperm binding protein
NP_004365.1
XP_016868509.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004374.4NP_004365.1  cytochrome c oxidase subunit 6C

    See identical proteins and their annotated locations for NP_004365.1

    Status: REVIEWED

    Source sequence(s)
    AC105328
    Consensus CDS
    CCDS6284.1
    UniProtKB/Swiss-Prot
    P09669
    UniProtKB/TrEMBL
    A0A024R9B7
    Related
    ENSP00000428895.1, ENST00000520468.7
    Conserved Domains (1) summary
    cd00927
    Location:674
    Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    99877865..99893707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013020.1XP_016868509.1  cytochrome c oxidase subunit 6C isoform X1

    UniProtKB/Swiss-Prot
    P09669
    UniProtKB/TrEMBL
    A0A024R9B7
    Related
    ENSP00000428150.1, ENST00000520271.5
    Conserved Domains (1) summary
    cd00927
    Location:674
    Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
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