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GPR151 G protein-coupled receptor 151 [ Homo sapiens (human) ]

Gene ID: 134391, updated on 11-Jun-2021

Summary

Official Symbol
GPR151provided by HGNC
Official Full Name
G protein-coupled receptor 151provided by HGNC
Primary source
HGNC:HGNC:23624
See related
Ensembl:ENSG00000173250 MIM:618487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; PGR7; GALR4; GALRL; GPCR-2037
Summary
This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

See GPR151 in Genome Data Viewer
Location:
5q32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (146513144..146516190, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145892707..145895753, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378213 Neighboring gene transcription elongation regulator 1 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene RNA, 7SL, cytoplasmic 791, pseudogene

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 151
Names
G-protein coupled receptor PGR7
galanin receptor 4
galanin-receptor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194251.3NP_919227.2  G-protein coupled receptor 151

    See identical proteins and their annotated locations for NP_919227.2

    Status: VALIDATED

    Source sequence(s)
    AC011375
    Consensus CDS
    CCDS34266.1
    UniProtKB/Swiss-Prot
    Q8TDV0
    Related
    ENSP00000308733.2, ENST00000311104.3
    Conserved Domains (1) summary
    cd15002
    Location:38317
    7tmA_GPR151; G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    146513144..146516190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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