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Dnmt3b DNA methyltransferase 3B [ Mus musculus (house mouse) ]

Gene ID: 13436, updated on 29-Jan-2023

Summary

Official Symbol
Dnmt3bprovided by MGI
Official Full Name
DNA methyltransferase 3Bprovided by MGI
Primary source
MGI:MGI:1261819
See related
Ensembl:ENSMUSG00000027478 AllianceGenome:MGI:1261819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MmuIIIB
Summary
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.1), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dnmt3b in Genome Data Viewer
Location:
2; 2 H1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153491332..153529650)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153649411..153687730)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4-like Neighboring gene RIKEN cDNA 4930404H24 gene Neighboring gene COMM domain containing 7 Neighboring gene DNA methyltransferase 3B, pseudogene 1 Neighboring gene sorting nexin 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124407

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA (cytosine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA (cytosine-5-)-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA (cytosine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates TAS
Traceable Author Statement
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in C-5 methylation of cytosine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within C-5 methylation of cytosine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in C-5 methylation of cytosine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA methylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA methylation involved in embryo development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within DNA methylation involved in embryo development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein-containing complex localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression by genomic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA (cytosine-5)-methyltransferase 3B
Names
DNA MTase MmuIIIB
DNA methyltransferase MmuIIIB
NP_001003960.2
NP_001003961.2
NP_001003963.2
NP_001116469.1
NP_001258673.1
NP_001258674.1
NP_001258675.1
NP_001258676.1
NP_034198.3
XP_006498745.1
XP_006498746.1
XP_006498747.1
XP_006498748.1
XP_006498749.1
XP_006498750.1
XP_006498751.1
XP_006498752.1
XP_030103068.1
XP_030103075.1
XP_030103077.1
XP_030103078.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003960.4NP_001003960.2  DNA (cytosine-5)-methyltransferase 3B isoform 2

    See identical proteins and their annotated locations for NP_001003960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (2, also known as Dnmt3b2) is shorter than isoform 5. Variants 2 and 7 encode the same isoform (2).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16913.1
    UniProtKB/Swiss-Prot
    O88509
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000080334.7, ENSMUST00000081628.13
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:560722
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  2. NM_001003961.4NP_001003961.2  DNA (cytosine-5)-methyltransferase 3B isoform 1

    See identical proteins and their annotated locations for NP_001003961.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 5. The encoded isoform (1, also known as Dnmt3b1) is shorter than isoform 5. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16914.1
    UniProtKB/Swiss-Prot
    O88509, O88511
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000105396.3, ENSMUST00000109774.9
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:580742
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  3. NM_001003963.4NP_001003963.2  DNA (cytosine-5)-methyltransferase 3B isoform 4

    See identical proteins and their annotated locations for NP_001003963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (4, also known as Dnmt3b6) is shorter than isoform 5. Variants 4 and 8 encode the same isoform (4).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16915.1
    UniProtKB/TrEMBL
    Q3KR45, Q541E5
    Related
    ENSMUSP00000086370.6, ENSMUST00000088976.12
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:580742
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  4. NM_001122997.2NP_001116469.1  DNA (cytosine-5)-methyltransferase 3B isoform 5

    See identical proteins and their annotated locations for NP_001116469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS50759.1
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000105393.2, ENSMUST00000109771.2
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:581743
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  5. NM_001271744.1NP_001258673.1  DNA (cytosine-5)-methyltransferase 3B isoform 1

    See identical proteins and their annotated locations for NP_001258673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 5. The encoded isoform (1, also known as Dnmt3b1) is shorter than isoform 5. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16914.1
    UniProtKB/Swiss-Prot
    O88509, O88511
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000072761.4, ENSMUST00000072997.10
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:580742
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  6. NM_001271745.1NP_001258674.1  DNA (cytosine-5)-methyltransferase 3B isoform 2

    See identical proteins and their annotated locations for NP_001258674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (2, also known as Dnmt3b2) is shorter than isoform 5. Variants 2 and 7 encode the same isoform (2).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16913.1
    UniProtKB/Swiss-Prot
    O88509
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000105395.2, ENSMUST00000109773.8
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:560722
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  7. NM_001271746.1NP_001258675.1  DNA (cytosine-5)-methyltransferase 3B isoform 4

    See identical proteins and their annotated locations for NP_001258675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (4, also known as Dnmt3b6) is shorter than isoform 5. Variants 4 and 8 encode the same isoform (4).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16915.1
    UniProtKB/TrEMBL
    Q3KR45, Q541E5
    Related
    ENSMUSP00000105394.2, ENSMUST00000109772.8
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:580742
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  8. NM_001271747.1NP_001258676.1  DNA (cytosine-5)-methyltransferase 3B isoform 3

    See identical proteins and their annotated locations for NP_001258676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (3, also known as Dnmt3b3) is shorter than isoform 5. Variants 3 and 9 encode the same isoform (3).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16916.1
    UniProtKB/Swiss-Prot
    O88509
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000099440.2, ENSMUST00000103151.8
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:560722
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  9. NM_010068.5NP_034198.3  DNA (cytosine-5)-methyltransferase 3B isoform 3

    See identical proteins and their annotated locations for NP_034198.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (3, also known as Dnmt3b3) is shorter than isoform 5. Variants 3 and 9 encode the same isoform (3).
    Source sequence(s)
    AL929021, BC105922, BQ770921, CJ067523
    Consensus CDS
    CCDS16916.1
    UniProtKB/Swiss-Prot
    O88509
    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000099439.4, ENSMUST00000103150.10
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:560722
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    153491332..153529650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498684.4XP_006498747.1  DNA (cytosine-5)-methyltransferase 3B isoform X3

    See identical proteins and their annotated locations for XP_006498747.1

    UniProtKB/TrEMBL
    Q3KR45
    Related
    ENSMUSP00000051830.8, ENSMUST00000056495.14
    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:581743
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:436555
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  2. XM_030247208.2XP_030103068.1  DNA (cytosine-5)-methyltransferase 3B isoform X6

    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:561723
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  3. XM_030247217.2XP_030103077.1  DNA (cytosine-5)-methyltransferase 3B isoform X11

    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:561723
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  4. XM_030247218.1XP_030103078.1  DNA (cytosine-5)-methyltransferase 3B isoform X6

    Conserved Domains (3) summary
    cd05835
    Location:230316
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:561723
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:416535
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  5. XM_006498682.1XP_006498745.1  DNA (cytosine-5)-methyltransferase 3B isoform X1

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:593755
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:448567
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  6. XM_006498687.2XP_006498750.1  DNA (cytosine-5)-methyltransferase 3B isoform X7

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:593755
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:448567
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  7. XM_006498683.1XP_006498746.1  DNA (cytosine-5)-methyltransferase 3B isoform X2

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:592754
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:448567
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  8. XM_006498688.4XP_006498751.1  DNA (cytosine-5)-methyltransferase 3B isoform X8

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:592754
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:448567
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  9. XM_006498685.2XP_006498748.1  DNA (cytosine-5)-methyltransferase 3B isoform X4

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:573735
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:428547
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  10. XM_006498686.2XP_006498749.1  DNA (cytosine-5)-methyltransferase 3B isoform X5

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:572734
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:428547
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  11. XM_030247215.2XP_030103075.1  DNA (cytosine-5)-methyltransferase 3B isoform X9

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:573735
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:428547
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
  12. XM_006498689.4XP_006498752.1  DNA (cytosine-5)-methyltransferase 3B isoform X10

    Conserved Domains (3) summary
    cd05835
    Location:242328
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:572734
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:428547
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

RNA

  1. XR_374399.2 RNA Sequence