Dnmt3b DNA methyltransferase 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnmt3bprovided by MGI
Official Full Name: DNA methyltransferase 3Bprovided by MGI
Primary source: MGI:MGI:1261819
See related: Ensembl:ENSMUSG00000027478 AllianceGenome:MGI:1261819
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MmuIIIB
Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.1), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2; 2 H1

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153491332..153529650)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153649411..153687730)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B.
Title: Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B.
DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells.
Title: DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells.
DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis.
Title: DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis.
DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia.
Title: DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia.
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Title: TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with beta-Catenin.
Title: Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with β-Catenin.
Gene expression levels of DNA methyltransferase enzymes in Shank3-deficient mouse model of autism during early development.
Title: Gene expression levels of DNA methyltransferase enzymes in Shank3-deficient mouse model of autism during early development.
PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
Title: PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
Dnmt3b Deficiency in Myf5(+)-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Title: Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
Title: Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.

Submit: New GeneRIF Correction See all GeneRIFs (129)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:516618

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:467533

UniSTS:472909 (e-PCR)
- UniSTS:472909

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:472909

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:467534

NoName (e-PCR)
- UniSTS:548451

NoName (e-PCR)
- UniSTS:548452

NoName (e-PCR)
- UniSTS:548453

NoName (e-PCR)
- UniSTS:548454

UniSTS:525685 (e-PCR)
- UniSTS:525685

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525685

UniSTS:525686 (e-PCR)
- UniSTS:525686

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525686

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525687

Dnmt3b (e-PCR), detects polymorphism
- UniSTS:525699

Homology

Homologs of the Dnmt3b gene: The Dnmt3b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 291 organisms have orthologs with human gene Dnmt3b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IDA Inferred from Direct Assay more info	PubMed
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	TAS Traceable Author Statement more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C-5 methylation of cytosine	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within C-5 methylation of cytosine	IDA Inferred from Direct Assay more info	PubMed
involved_in C-5 methylation of cytosine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA methylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA methylation involved in embryo development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within DNA methylation involved in embryo development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression by genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: DNA (cytosine-5)-methyltransferase 3B

Names: DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB

NP_001003960.2

EC 2.1.1.37

NP_001003961.2

EC 2.1.1.37

NP_001003963.2

EC 2.1.1.37

NP_001116469.1

EC 2.1.1.37

NP_001258673.1

EC 2.1.1.37

NP_001258674.1

EC 2.1.1.37

NP_001258675.1

EC 2.1.1.37

NP_001258676.1

EC 2.1.1.37

NP_034198.3

EC 2.1.1.37

XP_006498745.1

EC 2.1.1.37

XP_006498746.1

EC 2.1.1.37

XP_006498747.1

EC 2.1.1.37

XP_006498748.1

EC 2.1.1.37

XP_006498749.1

EC 2.1.1.37

XP_006498750.1

EC 2.1.1.37

XP_006498751.1

EC 2.1.1.37

XP_006498752.1

EC 2.1.1.37

XP_030103068.1

EC 2.1.1.37

XP_030103075.1

EC 2.1.1.37

XP_030103077.1

EC 2.1.1.37

XP_030103078.1

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003960.4 → NP_001003960.2 DNA (cytosine-5)-methyltransferase 3B isoform 2

See identical proteins and their annotated locations for NP_001003960.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (2, also known as Dnmt3b2) is shorter than isoform 5. Variants 2 and 7 encode the same isoform (2).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16913.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000080334.7, ENSMUST00000081628.13

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001003961.4 → NP_001003961.2 DNA (cytosine-5)-methyltransferase 3B isoform 1

See identical proteins and their annotated locations for NP_001003961.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 5. The encoded isoform (1, also known as Dnmt3b1) is shorter than isoform 5. Variants 1 and 6 encode the same isoform (1).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16914.1

UniProtKB/Swiss-Prot

O88509, O88511

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000105396.3, ENSMUST00000109774.9

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001003963.4 → NP_001003963.2 DNA (cytosine-5)-methyltransferase 3B isoform 4

See identical proteins and their annotated locations for NP_001003963.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (4, also known as Dnmt3b6) is shorter than isoform 5. Variants 4 and 8 encode the same isoform (4).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16915.1

UniProtKB/TrEMBL

Q3KR45, Q541E5

Related

ENSMUSP00000086370.6, ENSMUST00000088976.12

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001122997.2 → NP_001116469.1 DNA (cytosine-5)-methyltransferase 3B isoform 5

See identical proteins and their annotated locations for NP_001116469.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) encodes the longest isoform (5).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS50759.1

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000105393.2, ENSMUST00000109771.2

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:581 → 743

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271744.1 → NP_001258673.1 DNA (cytosine-5)-methyltransferase 3B isoform 1

See identical proteins and their annotated locations for NP_001258673.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 5. The encoded isoform (1, also known as Dnmt3b1) is shorter than isoform 5. Variants 1 and 6 encode the same isoform (1).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16914.1

UniProtKB/Swiss-Prot

O88509, O88511

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000072761.4, ENSMUST00000072997.10

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271745.1 → NP_001258674.1 DNA (cytosine-5)-methyltransferase 3B isoform 2

See identical proteins and their annotated locations for NP_001258674.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (2, also known as Dnmt3b2) is shorter than isoform 5. Variants 2 and 7 encode the same isoform (2).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16913.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000105395.2, ENSMUST00000109773.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271746.1 → NP_001258675.1 DNA (cytosine-5)-methyltransferase 3B isoform 4

See identical proteins and their annotated locations for NP_001258675.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (4, also known as Dnmt3b6) is shorter than isoform 5. Variants 4 and 8 encode the same isoform (4).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16915.1

UniProtKB/TrEMBL

Q3KR45, Q541E5

Related

ENSMUSP00000105394.2, ENSMUST00000109772.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:580 → 742

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_001271747.1 → NP_001258676.1 DNA (cytosine-5)-methyltransferase 3B isoform 3

See identical proteins and their annotated locations for NP_001258676.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (3, also known as Dnmt3b3) is shorter than isoform 5. Variants 3 and 9 encode the same isoform (3).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16916.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000099440.2, ENSMUST00000103151.8

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
NM_010068.5 → NP_034198.3 DNA (cytosine-5)-methyltransferase 3B isoform 3

See identical proteins and their annotated locations for NP_034198.3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and contains multiple differences in the coding region, but maintains the reading frame, compared to variant 5. The encoded isoform (3, also known as Dnmt3b3) is shorter than isoform 5. Variants 3 and 9 encode the same isoform (3).

Source sequence(s)

AL929021, BC105922, BQ770921, CJ067523

Consensus CDS

CCDS16916.1

UniProtKB/Swiss-Prot

O88509

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000099439.4, ENSMUST00000103150.10

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:560 → 722

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

153491332..153529650

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498684.4 → XP_006498747.1 DNA (cytosine-5)-methyltransferase 3B isoform X3

See identical proteins and their annotated locations for XP_006498747.1

UniProtKB/TrEMBL

Q3KR45

Related

ENSMUSP00000051830.8, ENSMUST00000056495.14

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:581 → 743

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:436 → 555

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_030247208.2 → XP_030103068.1 DNA (cytosine-5)-methyltransferase 3B isoform X6

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:561 → 723

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_030247217.2 → XP_030103077.1 DNA (cytosine-5)-methyltransferase 3B isoform X11

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:561 → 723

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_030247218.1 → XP_030103078.1 DNA (cytosine-5)-methyltransferase 3B isoform X6

Conserved Domains (3) summary

cd05835
Location:230 → 316

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:561 → 723

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:416 → 535

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498682.1 → XP_006498745.1 DNA (cytosine-5)-methyltransferase 3B isoform X1

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:593 → 755

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498687.2 → XP_006498750.1 DNA (cytosine-5)-methyltransferase 3B isoform X7

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:593 → 755

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498683.1 → XP_006498746.1 DNA (cytosine-5)-methyltransferase 3B isoform X2

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:592 → 754

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498688.4 → XP_006498751.1 DNA (cytosine-5)-methyltransferase 3B isoform X8

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:592 → 754

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:448 → 567

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498685.2 → XP_006498748.1 DNA (cytosine-5)-methyltransferase 3B isoform X4

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:573 → 735

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498686.2 → XP_006498749.1 DNA (cytosine-5)-methyltransferase 3B isoform X5

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:572 → 734

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_030247215.2 → XP_030103075.1 DNA (cytosine-5)-methyltransferase 3B isoform X9

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:573 → 735

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
XM_006498689.4 → XP_006498752.1 DNA (cytosine-5)-methyltransferase 3B isoform X10

Conserved Domains (3) summary

cd05835
Location:242 → 328

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

COG0270
Location:572 → 734

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

cd11728
Location:428 → 547

ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)