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Dnah8 dynein, axonemal, heavy chain 8 [ Mus musculus (house mouse) ]

Gene ID: 13417, updated on 5-Mar-2024

Summary

Official Symbol
Dnah8provided by MGI
Official Full Name
dynein, axonemal, heavy chain 8provided by MGI
Primary source
MGI:MGI:107714
See related
Ensembl:ENSMUSG00000033826 AllianceGenome:MGI:107714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPase; Dnahc8; Hst6.7b; P1-Loop
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement and outer dynein arm assembly. Located in sperm principal piece. Is expressed in brain and thymus primordium. Used to study spermatogenic failure 46. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 24.8) and thymus adult (RPKM 3.7) See more
Orthologs
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Genomic context

See Dnah8 in Genome Data Viewer
Location:
17 A3.3; 17 15.71 cM
Exon count:
94
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30845909..31094736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30626935..30875762)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8666 Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene glyoxalase 1 Neighboring gene predicted gene, 24661 Neighboring gene predicted gene, 41561 Neighboring gene STARR-seq mESC enhancer starr_42315 Neighboring gene glucagon-like peptide 1 receptor Neighboring gene predicted gene, 41562

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of outer dynein arm ISM
Inferred from Sequence Model
more info
PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynein axonemal heavy chain 8
Names
axonemal beta dynein heavy chain 8
axonemal dynein heavy chain 8 Dnahc8
ciliary dynein heavy chain 8
dynein heavy chain 8, axonemal
dynein, axon, heavy chain 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013811.4NP_038839.2  dynein axonemal heavy chain 8

    See identical proteins and their annotated locations for NP_038839.2

    Status: VALIDATED

    Source sequence(s)
    AC165951, AC165962, AC166166, AC174471
    Consensus CDS
    CCDS37541.1
    UniProtKB/Swiss-Prot
    E9Q010, O08830, Q3V0D2, Q91V63, Q91XP8, Q91XP9, Q91XQ0, Q99MH8, Q9QY72
    Related
    ENSMUSP00000157469.2, ENSMUST00000236140.2
    Conserved Domains (6) summary
    COG5245
    Location:13584379
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:382936
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:15091914
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:20492376
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:30313293
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:44334728
    Dynein_C; Dynein heavy chain C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    30845909..31094736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160293.1XP_036016186.1  dynein axonemal heavy chain 8 isoform X1

    Conserved Domains (4) summary
    COG5245
    Location:13914412
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:382969
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:20822409
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:44664761
    Dynein_C; Dynein heavy chain C-terminal domain