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UBE2QL1 ubiquitin conjugating enzyme E2 Q family like 1 [ Homo sapiens (human) ]

Gene ID: 134111, updated on 13-May-2022

Summary

Official Symbol
UBE2QL1provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Q family like 1provided by HGNC
Primary source
HGNC:HGNC:37269
See related
Ensembl:ENSG00000215218 MIM:615832; AllianceGenome:HGNC:37269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 12.4), heart (RPKM 3.3) and 7 other tissues See more
Orthologs
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Genomic context

See UBE2QL1 in Genome Data Viewer
Location:
5p15.31
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (6448859..6496723)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (6379225..6427083)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (6448972..6496836)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:6408294-6409493 Neighboring gene uncharacterized LOC124900933 Neighboring gene uncharacterized LOC105374639 Neighboring gene long intergenic non-protein coding RNA 1018 Neighboring gene NOP2/Sun RNA methyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25076, FLJ39293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2Q-like protein 1
Names
E2Q-like ubiquitin-conjugating enzyme 1
ubiquitin-conjugating enzyme E2Q family-like 1
NP_001138633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145161.3NP_001138633.1  ubiquitin-conjugating enzyme E2Q-like protein 1

    See identical proteins and their annotated locations for NP_001138633.1

    Status: VALIDATED

    Source sequence(s)
    AC093307, BC127723
    Consensus CDS
    CCDS47189.1
    UniProtKB/Swiss-Prot
    A1L167
    Related
    ENSP00000382713.3, ENST00000399816.4
    Conserved Domains (1) summary
    cl00154
    Location:1115
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    6448859..6496723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791776.1 Reference GRCh38.p14 PATCHES

    Range
    152669..200533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    6379225..6427083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)