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ADORA1 adenosine A1 receptor [ Homo sapiens (human) ]

Gene ID: 134, updated on 9-Jan-2022

Summary

Official Symbol
ADORA1provided by HGNC
Official Full Name
adenosine A1 receptorprovided by HGNC
Primary source
HGNC:HGNC:262
See related
Ensembl:ENSG00000163485 MIM:102775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDC7
Summary
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more
Orthologs
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Genomic context

See ADORA1 in Genome Data Viewer
Location:
1q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (203127705..203167405)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203096854..203136533)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene uncharacterized LOC105371687 Neighboring gene myogenin promoter associated myogenic regulatory antisense long non coding RNA Neighboring gene myogenin Neighboring gene myosin binding protein H Neighboring gene chitinase 3 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heterotrimeric G-protein binding IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables purine nucleoside binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neurotrophin production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in phagocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nucleoside transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glomerular filtration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of respiratory gaseous exchange by nervous system process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in relaxation of vascular associated smooth muscle IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axolemma IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenosine receptor A1
Names
adenosine A1 receptor variant 1
adenosine A1 receptor variant 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052917.1 RefSeqGene

    Range
    5022..44701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000674.3NP_000665.1  adenosine receptor A1 isoform 1

    See identical proteins and their annotated locations for NP_000665.1

    Status: REVIEWED

    Source sequence(s)
    AC105940, BU740906, DB171678, L22214
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000338435.4, ENST00000337894.9
    Conserved Domains (2) summary
    pfam00001
    Location:26288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:18137
    7tm_4; Olfactory receptor
  2. NM_001048230.2NP_001041695.1  adenosine receptor A1 isoform 1

    See identical proteins and their annotated locations for NP_001041695.1

    Status: REVIEWED

    Source sequence(s)
    AC105940, AK127752, BU740906, DA343445
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000356205.4, ENST00000367236.8
    Conserved Domains (2) summary
    pfam00001
    Location:26288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:18137
    7tm_4; Olfactory receptor
  3. NM_001365065.1NP_001351994.1  adenosine receptor A1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC105940
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_001365066.1NP_001351995.1  adenosine receptor A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105940
    Related
    ENSP00000483953.1, ENST00000618295.1
    Conserved Domains (2) summary
    cd14964
    Location:1026
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1183
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    203127705..203167405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244901.1XP_005244958.1  adenosine receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_005244958.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_005244902.4XP_005244959.1  adenosine receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_005244959.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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