ADORA1 adenosine A1 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADORA1provided by HGNC
Official Full Name: adenosine A1 receptorprovided by HGNC
Primary source: HGNC:HGNC:262
See related: Ensembl:ENSG00000163485 MIM:102775
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RDC7
Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (203127705..203167405)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (203096854..203136533)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasmacytoid dendritic cells recruited by HIF-1alpha/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.
Title: Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.
Expression of ADR-alpha1, 2 and ADR-beta2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.
Title: Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.
NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization.
Title: NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization.
ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3beta/beta-catenin signaling.
Title: ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling.
ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.
Title: ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.
Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
Title: Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels.
Title: Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels.
Functional Impact of the G279S Substitution in the Adenosine A1-Receptor (A1R-G279S(7.44)), a Mutation Associated with Parkinson's Disease.
Title: Functional Impact of the G279S Substitution in the Adenosine A1-Receptor (A1R-G279S7.44), a Mutation Associated with Parkinson's Disease.
ADORA1 role in the tumor immune evasion.ADORA1 regulates tumor PD-L1 expression.
Title: ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis.
A2AR-A1R heterodimerization is proposed as the molecular mechanism enabling the NHE-independent control of renal oxygen consumption .
Title: Adenosine A2A receptor blocks the A 1 receptor inhibition of renal Na + transport and oxygen consumption.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-76157 (e-PCR)
- UniSTS:59052

D1S1699 (e-PCR)
- UniSTS:12997

GDB:452605 (e-PCR)
- UniSTS:157389

Homology

Homologs of the ADORA1 gene: The ADORA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 266 organisms have orthologs with human gene ADORA1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables purine nucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurotrophin production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron death	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nucleoside transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of glomerular filtration	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of respiratory gaseous exchange by nervous system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in relaxation of vascular associated smooth muscle	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in integral component of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in integral component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in integral component of presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: adenosine receptor A1

Names: adenosine A1 receptor variant 1; adenosine A1 receptor variant 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052917.1 RefSeqGene

Range

5022..44701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000674.3 → NP_000665.1 adenosine receptor A1 isoform 1

See identical proteins and their annotated locations for NP_000665.1

Status: REVIEWED

Source sequence(s)

AC105940, BU740906, DB171678, L22214

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

P30542

Related

ENSP00000338435.4, ENST00000337894.9

Conserved Domains (2) summary

pfam00001
Location:26 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:18 → 137

7tm_4; Olfactory receptor
NM_001048230.2 → NP_001041695.1 adenosine receptor A1 isoform 1

See identical proteins and their annotated locations for NP_001041695.1

Status: REVIEWED

Source sequence(s)

AC105940, AK127752, BU740906, DA343445

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

P30542

Related

ENSP00000356205.4, ENST00000367236.8

Conserved Domains (2) summary

pfam00001
Location:26 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:18 → 137

7tm_4; Olfactory receptor
NM_001365065.1 → NP_001351994.1 adenosine receptor A1 isoform 2

Status: REVIEWED

Source sequence(s)

AC105940

Conserved Domains (2) summary

cd14964
Location:58 → 74

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:46 → 231

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001365066.1 → NP_001351995.1 adenosine receptor A1 isoform 3

Status: REVIEWED

Source sequence(s)

AC105940

Related

ENSP00000483953.1, ENST00000618295.1

Conserved Domains (2) summary

cd14964
Location:10 → 26

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 183

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p13 Primary Assembly

Range

203127705..203167405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005244901.1 → XP_005244958.1 adenosine receptor A1 isoform X1

See identical proteins and their annotated locations for XP_005244958.1

UniProtKB/TrEMBL

B7Z1L9

Conserved Domains (2) summary

cd14964
Location:58 → 74

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:46 → 231

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_005244902.4 → XP_005244959.1 adenosine receptor A1 isoform X1

See identical proteins and their annotated locations for XP_005244959.1

UniProtKB/TrEMBL

B7Z1L9

Conserved Domains (2) summary

cd14964
Location:58 → 74

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:46 → 231

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily