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ADORA1 adenosine A1 receptor [ Homo sapiens (human) ]

Gene ID: 134, updated on 13-Mar-2020

Summary

Official Symbol
ADORA1provided by HGNC
Official Full Name
adenosine A1 receptorprovided by HGNC
Primary source
HGNC:HGNC:262
See related
Ensembl:ENSG00000163485 MIM:102775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDC7
Summary
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more
Orthologs

Genomic context

See ADORA1 in Genome Data Viewer
Location:
1q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (203127705..203167405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203096833..203136533)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene uncharacterized LOC105371687 Neighboring gene myogenin promoter associated myogenic regulatory antisense long non coding RNA Neighboring gene myogenin Neighboring gene myosin binding protein H Neighboring gene chitinase 3 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein binding IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
purine nucleoside binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cognition IEA
Inferred from Electronic Annotation
more info
 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of circadian sleep/wake cycle, non-REM sleep IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
phagocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleoside transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of glomerular filtration IEA
Inferred from Electronic Annotation
more info
 
regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of respiratory gaseous exchange by neurological system process IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
relaxation of vascular smooth muscle IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axolemma IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
calyx of Held IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenosine receptor A1
Names
adenosine A1 receptor variant 1
adenosine A1 receptor variant 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052917.1 RefSeqGene

    Range
    5022..44701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000674.3NP_000665.1  adenosine receptor A1 isoform 1

    See identical proteins and their annotated locations for NP_000665.1

    Status: REVIEWED

    Source sequence(s)
    AC105940, BU740906, DB171678, L22214
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000338435.4, ENST00000337894.9
    Conserved Domains (2) summary
    pfam00001
    Location:26288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:18137
    7tm_4; Olfactory receptor
  2. NM_001048230.2NP_001041695.1  adenosine receptor A1 isoform 1

    See identical proteins and their annotated locations for NP_001041695.1

    Status: REVIEWED

    Source sequence(s)
    AC105940, AK127752, BU740906, DA343445
    Consensus CDS
    CCDS1434.1
    UniProtKB/Swiss-Prot
    P30542
    Related
    ENSP00000356205.4, ENST00000367236.8
    Conserved Domains (2) summary
    pfam00001
    Location:26288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:18137
    7tm_4; Olfactory receptor
  3. NM_001365065.1NP_001351994.1  adenosine receptor A1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC105940
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_001365066.1NP_001351995.1  adenosine receptor A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105940
    Related
    ENSP00000483953.1, ENST00000618295.1
    Conserved Domains (2) summary
    cd14964
    Location:1026
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1183
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    203127705..203167405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244901.1XP_005244958.1  adenosine receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_005244958.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_005244902.4XP_005244959.1  adenosine receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_005244959.1

    UniProtKB/TrEMBL
    B7Z1L9
    Conserved Domains (2) summary
    cd14964
    Location:5874
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:46231
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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