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Dlx2 distal-less homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 13392, updated on 5-Dec-2018

Summary

Official Symbol
Dlx2provided by MGI
Official Full Name
distal-less homeobox 2provided by MGI
Primary source
MGI:MGI:94902
See related
Ensembl:ENSMUSG00000023391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlx-2; Tes-1; AW121999
Expression
Biased expression in whole brain E14.5 (RPKM 11.5), CNS E14 (RPKM 10.5) and 5 other tissues See more
Orthologs

Genomic context

See Dlx2 in Genome Data Viewer
Location:
2 C2; 2 42.65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (71543408..71546754, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (71381465..71384811, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene predicted gene, 46746 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 1 Neighboring gene predicted gene, 36857 Neighboring gene uncharacterized LOC105244193

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex GABAergic interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cerebral cortex GABAergic interneuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
subpallium development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein DLX-2
Names
DII A
homeobox protein TES-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010054.2NP_034184.1  homeobox protein DLX-2

    See identical proteins and their annotated locations for NP_034184.1

    Status: VALIDATED

    Source sequence(s)
    AK144652, BC094317
    Consensus CDS
    CCDS16117.1
    UniProtKB/Swiss-Prot
    P40764
    UniProtKB/TrEMBL
    Q52KJ2
    Related
    ENSMUSP00000024159.6, ENSMUST00000024159.7
    Conserved Domains (2) summary
    pfam00046
    Location:158211
    Homeobox; Homeobox domain
    pfam12413
    Location:54135
    DLL_N; Homeobox protein distal-less-like N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    71543408..71546754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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