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Dlx1 distal-less homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 13390, updated on 12-May-2024

Summary

Official Symbol
Dlx1provided by MGI
Official Full Name
distal-less homeobox 1provided by MGI
Primary source
MGI:MGI:94901
See related
Ensembl:ENSMUSG00000041911 AllianceGenome:MGI:94901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlx; DII B; Dlx-1
Summary
The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 29.9), frontal lobe adult (RPKM 28.2) and 4 other tissues See more
Orthologs
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Genomic context

See Dlx1 in Genome Data Viewer
Location:
2 C2; 2 42.61 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71358457..71364325)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71528113..71533981)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene histone aminotransferase 1 Neighboring gene VISTA enhancer mm55 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_04791 Neighboring gene STARR-seq mESC enhancer starr_04792 Neighboring gene distal-less homeobox 1, antisense Neighboring gene STARR-seq mESC enhancer starr_04793 Neighboring gene distal-less homeobox 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:71436893-71437193 Neighboring gene predicted gene, 36857

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within GABAergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within subpallium development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416985.1NP_001403914.1  homeobox protein DLX-1

    Status: REVIEWED

    Source sequence(s)
    AL928931
    UniProtKB/Swiss-Prot
    Q64317
  2. NM_001416986.1NP_001403915.1  homeobox protein DLX-1

    Status: REVIEWED

    Source sequence(s)
    AL928931
    UniProtKB/Swiss-Prot
    Q64317
  3. NM_001416987.1NP_001403916.1  homeobox protein DLX-1

    Status: REVIEWED

    Source sequence(s)
    AL928931
    UniProtKB/Swiss-Prot
    Q64317
  4. NM_010053.3NP_034183.1  homeobox protein DLX-1

    See identical proteins and their annotated locations for NP_034183.1

    Status: REVIEWED

    Source sequence(s)
    AL928931
    Consensus CDS
    CCDS16116.1
    UniProtKB/Swiss-Prot
    Q64317
    Related
    ENSMUSP00000042413.4, ENSMUST00000037119.4
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71358457..71364325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498672.3XP_006498735.1  homeobox protein DLX-1 isoform X1

    See identical proteins and their annotated locations for XP_006498735.1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain