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Dlx1 distal-less homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 13390, updated on 5-Dec-2018

Summary

Official Symbol
Dlx1provided by MGI
Official Full Name
distal-less homeobox 1provided by MGI
Primary source
MGI:MGI:94901
See related
Ensembl:ENSMUSG00000041911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlx; Dlx-1
Summary
The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 29.9), frontal lobe adult (RPKM 28.2) and 4 other tissues See more
Orthologs

Genomic context

See Dlx1 in Genome Data Viewer
Location:
2 C2; 2 42.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (71528113..71533981)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (71367502..71372037)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene predicted gene, 46746 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 2 Neighboring gene predicted gene, 36857

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex GABAergic interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cerebral cortex GABAergic interneuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
subpallium development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein DLX-1
Names
DII B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010053.2NP_034183.1  homeobox protein DLX-1

    See identical proteins and their annotated locations for NP_034183.1

    Status: REVIEWED

    Source sequence(s)
    AL928931, BC079609
    Consensus CDS
    CCDS16116.1
    UniProtKB/Swiss-Prot
    Q64317
    Related
    ENSMUSP00000042413.3, ENSMUST00000037119.3
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    71528113..71533981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498671.3XP_006498734.1  homeobox protein DLX-1 isoform X1

    See identical proteins and their annotated locations for XP_006498734.1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  2. XM_017315311.1XP_017170800.1  homeobox protein DLX-1 isoform X1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  3. XM_006498673.3XP_006498736.1  homeobox protein DLX-1 isoform X1

    See identical proteins and their annotated locations for XP_006498736.1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  4. XM_017315307.1XP_017170796.1  homeobox protein DLX-1 isoform X1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  5. XM_017315305.1XP_017170794.1  homeobox protein DLX-1 isoform X1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  6. XM_006498672.3XP_006498735.1  homeobox protein DLX-1 isoform X1

    See identical proteins and their annotated locations for XP_006498735.1

    UniProtKB/Swiss-Prot
    Q64317
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
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