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COX6A2 cytochrome c oxidase subunit 6A2 [ Homo sapiens (human) ]

Gene ID: 1339, updated on 24-Nov-2020

Summary

Official Symbol
COX6A2provided by HGNC
Official Full Name
cytochrome c oxidase subunit 6A2provided by HGNC
Primary source
HGNC:HGNC:2279
See related
Ensembl:ENSG00000156885 MIM:602009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX6AH; COXVIAH; MC4DN18
Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 177.9), prostate (RPKM 30.1) and 1 other tissue See more
Orthologs

Genomic context

See COX6A2 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31427731..31428360, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31439052..31439749, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D Neighboring gene zinc finger protein 843 Neighboring gene armadillo repeat containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 6A2, mitochondrial
Names
COX VIa-M
cytochrome c oxidase polypeptide VIa-heart
cytochrome c oxidase subunit VIA-muscle
cytochrome c oxidase subunit VIa polypeptide 2
NP_005196.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005205.4NP_005196.1  cytochrome c oxidase subunit 6A2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_005196.1

    Status: REVIEWED

    Source sequence(s)
    BP319904
    Consensus CDS
    CCDS10712.1
    UniProtKB/Swiss-Prot
    Q02221
    Related
    ENSP00000287490.4, ENST00000287490.5
    Conserved Domains (1) summary
    cd00925
    Location:2695
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31427731..31428360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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