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Dll3 delta like canonical Notch ligand 3 [ Mus musculus (house mouse) ]

Gene ID: 13389, updated on 19-Apr-2019

Summary

Official Symbol
Dll3provided by MGI
Official Full Name
delta like canonical Notch ligand 3provided by MGI
Primary source
MGI:MGI:1096877
See related
Ensembl:ENSMUSG00000003436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pu; pudgy
Expression
Biased expression in CNS E11.5 (RPKM 28.4), whole brain E14.5 (RPKM 11.7) and 3 other tissues See more
Orthologs

Genomic context

See Dll3 in Genome Data Viewer
Location:
7 A3; 7 16.67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (28293555..28301785, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29078574..29086804, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene EP300 interacting inhibitor of differentiation 2B Neighboring gene selenoprotein V Neighboring gene translocase of inner mitochondrial membrane 50 Neighboring gene suppressor of Ty 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling, organism-specific biosystem (from KEGG)
    Notch signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Notch signaling, conserved biosystem (from KEGG)
    Notch signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Notch signaling pathway, organism-specific biosystem (from KEGG)
    Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, conserved biosystem (from KEGG)
    Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
    Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
    Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
Notch binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
somitogenesis IDA
Inferred from Direct Assay
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
delta-like protein 3
Names
M-Delta-3
delta-like 3
delta3
drosophila Delta homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007866.2NP_031892.2  delta-like protein 3 precursor

    See identical proteins and their annotated locations for NP_031892.2

    Status: VALIDATED

    Source sequence(s)
    BB868475, BC052002
    Consensus CDS
    CCDS39856.1
    UniProtKB/Swiss-Prot
    O88516
    UniProtKB/TrEMBL
    Q3UND5
    Related
    ENSMUSP00000103951.3, ENSMUST00000108315.3
    Conserved Domains (3) summary
    cd00054
    Location:277308
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:2585
    MNNL; N terminus of Notch ligand
    cl19567
    Location:156246
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    28293555..28301785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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