U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dll1 delta like canonical Notch ligand 1 [ Mus musculus (house mouse) ]

Gene ID: 13388, updated on 24-Jan-2023

Summary

Official Symbol
Dll1provided by MGI
Official Full Name
delta like canonical Notch ligand 1provided by MGI
Primary source
MGI:MGI:104659
See related
Ensembl:ENSMUSG00000014773 AllianceGenome:MGI:104659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Delta1
Summary
Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and regionalization. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of cell differentiation; and nephron tubule development. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 27.4), spleen adult (RPKM 17.2) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dll1 in Genome Data Viewer
Location:
17 A2; 17 8.95 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15587616..15597275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15367354..15376932, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7423 Neighboring gene predicted gene 10510 Neighboring gene uncharacterized LOC118568318 Neighboring gene family with sequence similarity 120, member B Neighboring gene predicted gene, 49668 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling involved in heart development IC
Inferred by Curator
more info
PubMed 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Notch signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in auditory receptor cell fate commitment NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebellar Purkinje cell layer structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellar molecular layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial tip cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of hemocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in in utero embryonic development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear auditory receptor cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lateral inhibition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lateral inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in left/right axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in loop of Henle development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of hemocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of neuroepithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in odontogenesis of dentin-containing tooth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proximal tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skin epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somite specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
delta-like protein 1
Names
delta like-1
delta-like 1
drosophila Delta homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379042.1NP_001365971.1  delta-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154378
    UniProtKB/Swiss-Prot
    Q6PFV7
    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2291
    MNNL; N-terminus of Notch ligand
  2. NM_007865.3NP_031891.2  delta-like protein 1 precursor

    See identical proteins and their annotated locations for NP_031891.2

    Status: VALIDATED

    Source sequence(s)
    BC065063, BQ768900
    Consensus CDS
    CCDS37452.1
    UniProtKB/Swiss-Prot
    Q61483, Q6PFV7
    Related
    ENSMUSP00000014917.8, ENSMUST00000014917.8
    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2291
    MNNL; N-terminus of Notch ligand

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15587616..15597275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160292.1XP_036016185.1  delta-like protein 1 isoform X1

    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2291
    MNNL; N-terminus of Notch ligand
  2. XM_011246267.3XP_011244569.1  delta-like protein 1 isoform X1

    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2291
    MNNL; N-terminus of Notch ligand