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Dll1 delta like canonical Notch ligand 1 [ Mus musculus (house mouse) ]

Gene ID: 13388, updated on 9-Jul-2019

Summary

Official Symbol
Dll1provided by MGI
Official Full Name
delta like canonical Notch ligand 1provided by MGI
Primary source
MGI:MGI:104659
See related
Ensembl:ENSMUSG00000014773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Delta1
Expression
Broad expression in CNS E11.5 (RPKM 27.4), spleen adult (RPKM 17.2) and 21 other tissues See more
Orthologs

Genomic context

See Dll1 in Genome Data Viewer
Location:
17 A2; 17 8.95 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (15367354..15376048, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (15504318..15512787, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7423 Neighboring gene predicted gene 10510 Neighboring gene family with sequence similarity 120, member B Neighboring gene proteasome (prosome, macropain) subunit, beta type 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development IC
Inferred by Curator
more info
PubMed 
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Notch signaling pathway involved in arterial endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
auditory receptor cell fate commitment NAS
Non-traceable Author Statement
more info
PubMed 
cell communication IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
cerebellar Purkinje cell layer structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar molecular layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial tip cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development NAS
Non-traceable Author Statement
more info
PubMed 
inner ear auditory receptor cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
lateral inhibition IDA
Inferred from Direct Assay
more info
PubMed 
lateral inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
left/right axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
loop of Henle development IEP
Inferred from Expression Pattern
more info
PubMed 
marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
neuron fate specification IDA
Inferred from Direct Assay
more info
PubMed 
neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth NAS
Non-traceable Author Statement
more info
PubMed 
organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
proximal tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somite specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-like protein 1
Names
delta like-1
delta-like 1
drosophila Delta homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007865.3NP_031891.2  delta-like protein 1 precursor

    See identical proteins and their annotated locations for NP_031891.2

    Status: VALIDATED

    Source sequence(s)
    BC065063, BQ768900
    Consensus CDS
    CCDS37452.1
    UniProtKB/Swiss-Prot
    Q61483
    Related
    ENSMUSP00000014917.7, ENSMUST00000014917.7
    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2290
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    15367354..15376048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246267.2XP_011244569.1  delta-like protein 1 isoform X1

    Conserved Domains (4) summary
    smart00051
    Location:158220
    DSL; delta serrate ligand
    cd00054
    Location:442477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:484514
    EGF; EGF-like domain
    pfam07657
    Location:2290
    MNNL; N terminus of Notch ligand
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