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Dkk1 dickkopf WNT signaling pathway inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 13380, updated on 8-Feb-2024

Summary

Official Symbol
Dkk1provided by MGI
Official Full Name
dickkopf WNT signaling pathway inhibitor 1provided by MGI
Primary source
MGI:MGI:1329040
See related
Ensembl:ENSMUSG00000024868 AllianceGenome:MGI:1329040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mdkk-1
Summary
Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including Wnt signaling pathway involved in somitogenesis; embryonic morphogenesis; and negative regulation of signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 1.6) and 6 other tissues See more
Orthologs
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Genomic context

See Dkk1 in Genome Data Viewer
Location:
19 C1; 19 25.16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (30523276..30526896, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (30545876..30549496, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45910 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 3 Neighboring gene cathepsin L pseudogene Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene STARR-seq mESC enhancer starr_45911 Neighboring gene STARR-seq mESC enhancer starr_45912 Neighboring gene STARR-seq mESC enhancer starr_45913 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit E1 pseudogene Neighboring gene ubiquitin-like 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables co-receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within head morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart induction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning or memory IDA
Inferred from Direct Assay
more info
PubMed 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in motor learning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Wnt-Frizzled-LRP5/6 complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mesodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
dickkopf-related protein 1
Names
dickkopf homolog 1
dickkopf-1
dickkopf-like protein 1
dkk-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010051.3NP_034181.2  dickkopf-related protein 1 precursor

    See identical proteins and their annotated locations for NP_034181.2

    Status: VALIDATED

    Source sequence(s)
    AC103405
    Consensus CDS
    CCDS29744.1
    UniProtKB/Swiss-Prot
    O54908, Q80UL5
    Related
    ENSMUSP00000025803.9, ENSMUST00000025803.9
    Conserved Domains (1) summary
    pfam04706
    Location:86142
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    30523276..30526896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)