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JMY junction mediating and regulatory protein, p53 cofactor [ Homo sapiens (human) ]

Gene ID: 133746, updated on 25-Nov-2021

Summary

Official Symbol
JMYprovided by HGNC
Official Full Name
junction mediating and regulatory protein, p53 cofactorprovided by HGNC
Primary source
HGNC:HGNC:28916
See related
Ensembl:ENSG00000152409 MIM:604279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WHAMM2; WHDC1L3
Expression
Ubiquitous expression in endometrium (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See JMY in Genome Data Viewer
Location:
5q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (79236131..79327215)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78531954..78623034)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene betaine--homocysteine S-methyltransferase Neighboring gene RNY3 pseudogene 1 Neighboring gene RPS3A pseudogene 20 Neighboring gene uncharacterized LOC102724530 Neighboring gene uncharacterized LOC101929201 Neighboring gene homer scaffold protein 1 Neighboring gene uncharacterized LOC107986426 Neighboring gene Sharpr-MPRA regulatory region 1837

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of selenium concentrations.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37870, MGC163496

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in 'de novo' actin filament nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in 'de novo' actin filament nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in actin polymerization-dependent cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
junction-mediating and -regulatory protein
Names
WAS protein homology region 2 domain containing 1-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152405.5NP_689618.4  junction-mediating and -regulatory protein

    See identical proteins and their annotated locations for NP_689618.4

    Status: VALIDATED

    Source sequence(s)
    AC016559, AC020898, AK095189, BC130624, BM668734, CN372786, DA435238
    Consensus CDS
    CCDS4047.3
    UniProtKB/Swiss-Prot
    Q8N9B5
    Related
    ENSP00000379441.4, ENST00000396137.5
    Conserved Domains (2) summary
    pfam15871
    Location:229582
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:654
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    79236131..79327215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248430.3XP_005248487.1  junction-mediating and -regulatory protein isoform X2

    Conserved Domains (2) summary
    pfam15871
    Location:229582
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:654
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated
  2. XM_011543155.3XP_011541457.1  junction-mediating and -regulatory protein isoform X1

    Conserved Domains (2) summary
    pfam15871
    Location:229582
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:654
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated
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