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JMY junction mediating and regulatory protein, p53 cofactor [ Homo sapiens (human) ]

Gene ID: 133746, updated on 27-Nov-2024

Summary

Official Symbol
JMYprovided by HGNC
Official Full Name
junction mediating and regulatory protein, p53 cofactorprovided by HGNC
Primary source
HGNC:HGNC:28916
See related
Ensembl:ENSG00000152409 MIM:604279; AllianceGenome:HGNC:28916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WHAMM2; WHDC1L3
Summary
Enables microtubule binding activity. Involved in cellular response to starvation. Located in autophagosome membrane; cell leading edge; and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Ubiquitous expression in endometrium (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See JMY in Genome Data Viewer
Location:
5q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (79236131..79327211)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (79720365..79811387)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78531954..78623034)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901011 Neighboring gene RNY3 pseudogene 1 Neighboring gene small nucleolar RNA SNORA18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16129 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:78532408-78533044 Neighboring gene Sharpr-MPRA regulatory region 9907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:78551199-78551987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:78553931-78554592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:78555253-78555912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:78557127-78557664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:78557665-78558202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:78559614-78560138 Neighboring gene RPS3A pseudogene 20 Neighboring gene uncharacterized LOC102724530 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:78641964-78643163 Neighboring gene uncharacterized LOC101929201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78676523-78677022 Neighboring gene homer scaffold protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22724 Neighboring gene uncharacterized LOC107986426 Neighboring gene Sharpr-MPRA regulatory region 1837

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ37870, MGC163496

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in 'de novo' actin filament nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 'de novo' actin filament nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in actin polymerization-dependent cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
junction-mediating and -regulatory protein
Names
WAS protein homology region 2 domain containing 1-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152405.5NP_689618.4  junction-mediating and -regulatory protein

    See identical proteins and their annotated locations for NP_689618.4

    Status: VALIDATED

    Source sequence(s)
    AC016559, AC020898, AK095189, BC130624, BM668734, CN372786, DA435238
    Consensus CDS
    CCDS4047.3
    UniProtKB/Swiss-Prot
    A1L4P5, B5MDS2, B5MDT0, Q8N9B5
    Related
    ENSP00000379441.4, ENST00000396137.5
    Conserved Domains (3) summary
    TIGR02168
    Location:446720
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15871
    Location:229582
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:654
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    79236131..79327211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    79720365..79811387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)