U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UGT3A1 UDP glycosyltransferase family 3 member A1 [ Homo sapiens (human) ]

Gene ID: 133688, updated on 22-Sep-2022

Summary

Official Symbol
UGT3A1provided by HGNC
Official Full Name
UDP glycosyltransferase family 3 member A1provided by HGNC
Primary source
HGNC:HGNC:26625
See related
Ensembl:ENSG00000145626 MIM:616383; AllianceGenome:HGNC:26625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 14.9), liver (RPKM 11.3) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UGT3A1 in Genome Data Viewer
Location:
5p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (35951006..36001022, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (36199267..36249286, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (35951108..36001124, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7574 Neighboring gene calcyphosine like Neighboring gene CAPSL divergent transcript Neighboring gene UDP glycosyltransferase family 3 member A2 Neighboring gene LMBR1 domain containing 2 Neighboring gene microRNA 580

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26528, FLJ34658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP-glycosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of UDP-N-acetylglucosamine transferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-glucuronosyltransferase 3A1
Names
UDP glycosyltransferase 3 family, polypeptide A1
UDPGT 3A1
NP_001165344.1
NP_689617.3
XP_005248300.1
XP_011512259.1
XP_011512260.1
XP_011512261.1
XP_047272663.1
XP_047272664.1
XP_047272665.1
XP_047272666.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171873.2NP_001165344.1  UDP-glucuronosyltransferase 3A1 isoform 2

    See identical proteins and their annotated locations for NP_001165344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in distinct 5' UTR and 3' UTRs, cause translation initiation at a downstream start codon and result in a frameshift and an early stop codon, compared to variant 1. The encoded isoform has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016612, BC035012
    Consensus CDS
    CCDS54841.1
    UniProtKB/Swiss-Prot
    Q6NUS8
    UniProtKB/TrEMBL
    A0A024R085
    Related
    ENSP00000487376.1, ENST00000625798.2
    Conserved Domains (1) summary
    pfam00201
    Location:26227
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_152404.4NP_689617.3  UDP-glucuronosyltransferase 3A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_689617.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112204, AI244517, AK315851
    Consensus CDS
    CCDS3913.1
    UniProtKB/Swiss-Prot
    Q6NUS8, Q96DM6
    UniProtKB/TrEMBL
    A8K444, B7Z3N0
    Related
    ENSP00000274278.3, ENST00000274278.8
    Conserved Domains (1) summary
    cl26154
    Location:23523
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    35951006..36001022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416709.1XP_047272665.1  UDP-glucuronosyltransferase 3A1 isoform X5

  2. XM_047416708.1XP_047272664.1  UDP-glucuronosyltransferase 3A1 isoform X4

  3. XM_011513957.3XP_011512259.1  UDP-glucuronosyltransferase 3A1 isoform X2

    Conserved Domains (2) summary
    PHA03392
    Location:191466
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    COG1819
    Location:46438
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  4. XM_047416707.1XP_047272663.1  UDP-glucuronosyltransferase 3A1 isoform X1

  5. XM_011513959.3XP_011512261.1  UDP-glucuronosyltransferase 3A1 isoform X4

    See identical proteins and their annotated locations for XP_011512261.1

    Conserved Domains (2) summary
    PHA03392
    Location:168443
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  6. XM_011513958.3XP_011512260.1  UDP-glucuronosyltransferase 3A1 isoform X3

    Related
    ENSP00000426100.1, ENST00000507113.5
    Conserved Domains (2) summary
    PHA03392
    Location:188463
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    COG1819
    Location:43435
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  7. XM_005248243.5XP_005248300.1  UDP-glucuronosyltransferase 3A1 isoform X4

    See identical proteins and their annotated locations for XP_005248300.1

    Conserved Domains (2) summary
    PHA03392
    Location:168443
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    COG1819
    Location:23415
    YjiC; UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism]
  8. XM_047416710.1XP_047272666.1  UDP-glucuronosyltransferase 3A1 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    36199267..36249286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)