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Dffb DNA fragmentation factor, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 13368, updated on 12-May-2024

Summary

Official Symbol
Dffbprovided by MGI
Official Full Name
DNA fragmentation factor, beta subunitprovided by MGI
Primary source
MGI:MGI:1196287
See related
Ensembl:ENSMUSG00000029027 AllianceGenome:MGI:1196287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAD; CPAN; 40kDa; DFF40; Didff; 5730477D02Rik
Summary
Enables DNA binding activity and nuclease activity. Predicted to be involved in apoptotic DNA fragmentation and apoptotic chromosome condensation. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be part of protein-containing complex. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.2), spleen adult (RPKM 5.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dffb in Genome Data Viewer
Location:
4 E2; 4 83.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154048904..154059578, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (153964447..153975121, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC039966 Neighboring gene RIKEN cDNA A430005L14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6293 Neighboring gene centrosomal protein 104 Neighboring gene predicted gene, 31566 Neighboring gene leucine rich repeat containing 47 Neighboring gene small integral membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA fragmentation factor subunit beta
Names
DFF-40
DNA fragmentation factor 40 kDa subunit
DNA fragmentation factor, 40 kD, beta subunit
DNase inhibited by DNA fragmentation factor
caspase-activated DNase
caspase-activated deoxyribonuclease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007859.4NP_031885.3  DNA fragmentation factor subunit beta

    See identical proteins and their annotated locations for NP_031885.3

    Status: VALIDATED

    Source sequence(s)
    AB009377, AK077619, BC053052
    Consensus CDS
    CCDS19004.1
    UniProtKB/Swiss-Prot
    O54788
    UniProtKB/TrEMBL
    Q7TS81, Q8BP66
    Related
    ENSMUSP00000030893.3, ENSMUST00000030893.3
    Conserved Domains (2) summary
    cd06535
    Location:783
    CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...
    pfam09230
    Location:103324
    DFF40; DNA fragmentation factor 40 kDa

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154048904..154059578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250184.3XP_011248486.1  DNA fragmentation factor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011248486.1

    Conserved Domains (1) summary
    pfam09230
    Location:37214
    DFF40; DNA fragmentation factor 40 kDa
  2. XM_030253183.2XP_030109043.1  DNA fragmentation factor subunit beta isoform X2

    Conserved Domains (1) summary
    pfam09230
    Location:37214
    DFF40; DNA fragmentation factor 40 kDa
  3. XM_036163646.1XP_036019539.1  DNA fragmentation factor subunit beta isoform X2

    Conserved Domains (1) summary
    pfam09230
    Location:37214
    DFF40; DNA fragmentation factor 40 kDa
  4. XM_011250183.4XP_011248485.1  DNA fragmentation factor subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011248485.1

    Conserved Domains (1) summary
    pfam09230
    Location:37214
    DFF40; DNA fragmentation factor 40 kDa
  5. XM_006538517.2XP_006538580.1  DNA fragmentation factor subunit beta isoform X1

    Conserved Domains (2) summary
    cd06535
    Location:783
    CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...
    pfam09230
    Location:103264
    DFF40; DNA fragmentation factor 40 kDa