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PRRC1 proline rich coiled-coil 1 [ Homo sapiens (human) ]

Gene ID: 133619, updated on 18-Aug-2020

Summary

Official Symbol
PRRC1provided by HGNC
Official Full Name
proline rich coiled-coil 1provided by HGNC
Primary source
HGNC:HGNC:28164
See related
Ensembl:ENSG00000164244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 18.8), endometrium (RPKM 14.7) and 25 other tissues See more
Orthologs

Genomic context

See PRRC1 in Genome Data Viewer
Location:
5q23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (127517624..127555085)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126853301..126890781)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379199 Neighboring gene multiple EGF like domains 10 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene 1 Neighboring gene uncharacterized LOC105379164 Neighboring gene cortexin 3 Neighboring gene coiled-coil domain containing 192 Neighboring gene cullin 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32875

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase A activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein PRRC1
Names
proline-rich and coiled-coil-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286808.2NP_001273737.1  protein PRRC1 isoform 1

    See identical proteins and their annotated locations for NP_001273737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010424, AJ441110, BX099255, DA808343
    Consensus CDS
    CCDS68943.1
    UniProtKB/Swiss-Prot
    Q96M27
    Related
    ENSP00000421965.2, ENST00000512635.2
    Conserved Domains (1) summary
    cl00866
    Location:263376
    NTPase_I-T; Protein of unknown function DUF84
  2. NM_130809.5NP_570721.1  protein PRRC1 isoform 2

    See identical proteins and their annotated locations for NP_570721.1

    Status: VALIDATED

    Description
    Transcript Variant: (2) has multiple differences in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC010424, BC017066, DA808343
    Consensus CDS
    CCDS4143.1
    UniProtKB/Swiss-Prot
    Q96M27
    Related
    ENSP00000296666.8, ENST00000296666.12
    Conserved Domains (1) summary
    cl00866
    Location:263376
    NTPase_I-T; Protein of unknown function DUF84

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    127517624..127555085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714529.3XP_006714592.1  protein PRRC1 isoform X1

    See identical proteins and their annotated locations for XP_006714592.1

    UniProtKB/Swiss-Prot
    Q96M27
    Conserved Domains (1) summary
    cl00866
    Location:263376
    NTPase_I-T; Protein of unknown function DUF84
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