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SLCO6A1 solute carrier organic anion transporter family member 6A1 [ Homo sapiens (human) ]

Gene ID: 133482, updated on 11-Jun-2021

Summary

Official Symbol
SLCO6A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 6A1provided by HGNC
Primary source
HGNC:HGNC:23613
See related
Ensembl:ENSG00000205359 MIM:613365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST; CT48; OATPY; OATP-I; OATP6A1
Expression
Restricted expression toward testis (RPKM 7.9) See more
Orthologs
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Genomic context

See SLCO6A1 in Genome Data Viewer
Location:
5q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (102371774..102502213, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (101707478..101834705, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 4C1 Neighboring gene RN7SK pseudogene 68 Neighboring gene long intergenic non-protein coding RNA 492 Neighboring gene long intergenic non-protein coding RNA 491 Neighboring gene VISTA enhancer hs1649 Neighboring gene uncharacterized LOC105379104

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Common variants conferring risk of schizophrenia.
GeneReviews: Not available
Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
solute carrier organic anion transporter family member 6A1
Names
cancer/testis antigen 48
gonad-specific transporter
organic anion-transporting polypeptide I
solute carrier family 21 member 19
testicular tissue protein Li 174
testis-specific organic anion transporter

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289002.2NP_001275931.1  solute carrier organic anion transporter family member 6A1 isoform 1

    See identical proteins and their annotated locations for NP_001275931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AC113417, AY273897, BG772379, DB513513, HY036202
    Consensus CDS
    CCDS34206.1
    UniProtKB/Swiss-Prot
    Q86UG4
    UniProtKB/TrEMBL
    A0A140VJU7
    Related
    ENSP00000369135.3, ENST00000379807.7
    Conserved Domains (3) summary
    cd06174
    Location:109330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:498551
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107665
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_001289004.2NP_001275933.1  solute carrier organic anion transporter family member 6A1 isoform 2

    See identical proteins and their annotated locations for NP_001275933.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC113417, BC034976, BM554439, DB513513, HY200806
    Consensus CDS
    CCDS75282.1
    UniProtKB/Swiss-Prot
    Q86UG4
    Related
    ENSP00000373671.3, ENST00000389019.7
    Conserved Domains (1) summary
    pfam03137
    Location:107603
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. NM_001308014.2NP_001294943.1  solute carrier organic anion transporter family member 6A1 isoform 3

    See identical proteins and their annotated locations for NP_001294943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks five internal exons that result in the loss of two in-frame segments in the coding region, and it also uses an alternate splice site in the 3' UTR, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC113417, AK131445, BC034976, DB513513
    Consensus CDS
    CCDS78042.1
    UniProtKB/Swiss-Prot
    Q86UG4
    UniProtKB/TrEMBL
    C9J020
    Related
    ENSP00000421990.1, ENST00000513675.1
    Conserved Domains (2) summary
    cd01330
    Location:245298
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107412
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  4. NM_173488.5NP_775759.3  solute carrier organic anion transporter family member 6A1 isoform 1

    See identical proteins and their annotated locations for NP_775759.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AC113417, AF505657, BM554439, DB513513, HY036202, HY200806
    Consensus CDS
    CCDS34206.1
    UniProtKB/Swiss-Prot
    Q86UG4
    UniProtKB/TrEMBL
    A0A140VJU7
    Related
    ENSP00000421339.1, ENST00000506729.6
    Conserved Domains (3) summary
    cd06174
    Location:109330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:498551
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107665
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    102371774..102502213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543148.2XP_011541450.1  solute carrier organic anion transporter family member 6A1 isoform X3

    Conserved Domains (3) summary
    cd01330
    Location:419472
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107586
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    cl21472
    Location:159251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_011543147.2XP_011541449.1  solute carrier organic anion transporter family member 6A1 isoform X2

    Conserved Domains (3) summary
    cd06174
    Location:109295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:463516
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107630
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. XM_005271874.3XP_005271931.1  solute carrier organic anion transporter family member 6A1 isoform X1

    See identical proteins and their annotated locations for XP_005271931.1

    UniProtKB/Swiss-Prot
    Q86UG4
    UniProtKB/TrEMBL
    A0A140VJU7
    Conserved Domains (3) summary
    cd06174
    Location:109330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:498551
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:107665
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  4. XM_011543153.2XP_011541455.1  solute carrier organic anion transporter family member 6A1 isoform X5

    See identical proteins and their annotated locations for XP_011541455.1

    UniProtKB/TrEMBL
    D3DSZ4
    Conserved Domains (2) summary
    cd01330
    Location:224277
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:1391
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  5. XM_011543150.1XP_011541452.1  solute carrier organic anion transporter family member 6A1 isoform X4

    Conserved Domains (2) summary
    cd01330
    Location:255308
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:1422
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  6. XM_011543154.3XP_011541456.1  solute carrier organic anion transporter family member 6A1 isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:109330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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