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EMB embigin [ Homo sapiens (human) ]

Gene ID: 133418, updated on 13-Feb-2019

Summary

Official Symbol
EMBprovided by HGNC
Official Full Name
embiginprovided by HGNC
Primary source
HGNC:HGNC:30465
See related
Ensembl:ENSG00000170571 MIM:615669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP70
Summary
This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]
Expression
Broad expression in bone marrow (RPKM 76.3), duodenum (RPKM 39.2) and 16 other tissues See more
Orthologs

Genomic context

See EMB in Genome Data Viewer
Location:
5q11.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (50396192..50443299, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49692026..49737234, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S30 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene poly(ADP-ribose) polymerase family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
embigin
Names
embigin homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198449.3NP_940851.1  embigin precursor

    See identical proteins and their annotated locations for NP_940851.1

    Status: REVIEWED

    Source sequence(s)
    AC091833, BC059398
    Consensus CDS
    CCDS3953.1
    UniProtKB/Swiss-Prot
    Q6PCB8
    Related
    ENSP00000302289.5, ENST00000303221.9
    Conserved Domains (2) summary
    smart00410
    Location:172254
    IG_like; Immunoglobulin like
    cl11960
    Location:82143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    50396192..50443299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543146.2XP_011541448.1  embigin isoform X1

    See identical proteins and their annotated locations for XP_011541448.1

    UniProtKB/Swiss-Prot
    Q6PCB8
    Related
    ENSP00000426404.1, ENST00000514111.1
    Conserved Domains (3) summary
    cd00096
    Location:127201
    Ig; Immunoglobulin domain
    smart00410
    Location:122204
    IG_like; Immunoglobulin like
    cl11960
    Location:3293
    Ig; Immunoglobulin domain
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