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EMB embigin [ Homo sapiens (human) ]

Gene ID: 133418, updated on 27-Nov-2024

Summary

Official Symbol
EMBprovided by HGNC
Official Full Name
embiginprovided by HGNC
Primary source
HGNC:HGNC:30465
See related
Ensembl:ENSG00000170571 MIM:615669; AllianceGenome:HGNC:30465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP70
Summary
This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]
Expression
Broad expression in bone marrow (RPKM 76.3), duodenum (RPKM 39.2) and 16 other tissues See more
Orthologs
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Genomic context

See EMB in Genome Data Viewer
Location:
5q11.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (50396192..50443345, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (51215328..51262447, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49692026..49737122, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:45288792-45289361 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:45385335-45386534 Neighboring gene NANOG hESC enhancer GRCh37_chr5:45398997-45399517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45694855-45695356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:45695357-45695856 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:45722136-45723335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45847424-45848170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:45848171-45848917 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46322424-46322954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46324015-46324544 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46323485-46324014 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:46339317-46339850 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46362710-46363410 Neighboring gene NANOG hESC enhancer GRCh37_chr5:46382059-46382560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49410739-49411304 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49411305-49411870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49429185-49430023 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49422693-49423236 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49428344-49429184 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:49418829-49419370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49423237-49423778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49431703-49432542 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49432543-49433382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:49433383-49434222 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:49436741-49437580 Neighboring gene NANOG hESC enhancer GRCh37_chr5:49539003-49539504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16001 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:49963094-49964293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22543 Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene poly(ADP-ribose) polymerase family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC71745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
embigin
Names
embigin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198449.3NP_940851.1  embigin precursor

    See identical proteins and their annotated locations for NP_940851.1

    Status: REVIEWED

    Source sequence(s)
    AC091833, BC059398
    Consensus CDS
    CCDS3953.1
    UniProtKB/Swiss-Prot
    B7Z6S3, B7Z902, Q6PCB8
    UniProtKB/TrEMBL
    D6RDX7
    Related
    ENSP00000302289.5, ENST00000303221.10
    Conserved Domains (2) summary
    smart00410
    Location:172254
    IG_like; Immunoglobulin like
    cl11960
    Location:82143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    50396192..50443345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543146.3XP_011541448.1  embigin isoform X1

    See identical proteins and their annotated locations for XP_011541448.1

    UniProtKB/Swiss-Prot
    Q6PCB8
    Conserved Domains (3) summary
    cd00096
    Location:127201
    Ig; Immunoglobulin domain
    smart00410
    Location:122204
    IG_like; Immunoglobulin like
    cl11960
    Location:3293
    Ig; Immunoglobulin domain
  2. XM_047416702.1XP_047272658.1  embigin isoform X1

    Related
    ENSP00000426404.1, ENST00000514111.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    51215328..51262447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351576.1XP_054207551.1  embigin isoform X1