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IL31RA interleukin 31 receptor A [ Homo sapiens (human) ]

Gene ID: 133396, updated on 11-Sep-2019

Summary

Official Symbol
IL31RAprovided by HGNC
Official Full Name
interleukin 31 receptor Aprovided by HGNC
Primary source
HGNC:HGNC:18969
See related
Ensembl:ENSG00000164509 MIM:609510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384
Summary
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL31RA in Genome Data Viewer
Location:
5q11.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55840334..55922854)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (55147207..55218682)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 4 Neighboring gene RNA, 5S ribosomal pseudogene 183 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 3 Neighboring gene interleukin 6 signal transducer Neighboring gene Sharpr-MPRA regulatory region 5314 Neighboring gene uncharacterized LOC441072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Amyloidosis, primary localized cutaneous, 2
MedGen: C3151404 OMIM: 613955 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of interleukin 31 receptor A (IL31RA) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine binding NAS
Non-traceable Author Statement
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade IEP
Inferred from Expression Pattern
more info
PubMed 
MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
defense response NAS
Non-traceable Author Statement
more info
PubMed 
homeostatic process NAS
Non-traceable Author Statement
more info
PubMed 
macrophage differentiation NAS
Non-traceable Author Statement
more info
PubMed 
monocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-31 receptor subunit alpha
Names
IL-31 receptor subunit alpha
IL-31R subunit alpha
class I cytokine receptor
cytokine receptor-like 3
gp130-like monocyte receptor
soluble type I cytokine receptor CRL3
zcytoR17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029436.1 RefSeqGene

    Range
    4979..76472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242636.1NP_001229565.1  interleukin-31 receptor subunit alpha isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon at the 5' end compared to variant 1. This results in use of an alternate translation initiation site, and a shorter isoform (2, also known as GPL745) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358117, BC110490
    Consensus CDS
    CCDS75245.1
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Related
    ENSP00000297015.4, ENST00000297015.7
    Conserved Domains (3) summary
    smart00060
    Location:434514
    FN3; Fibronectin type 3 domain
    cd00063
    Location:136235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:38132
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001242637.2NP_001229566.1  interleukin-31 receptor subunit alpha isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358740, AY499339
    Consensus CDS
    CCDS56365.1
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Related
    ENSP00000351935.5, ENST00000359040.10
    Conserved Domains (3) summary
    smart00060
    Location:453533
    FN3; Fibronectin type 3 domain
    cd00063
    Location:155254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:57151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_001242638.2NP_001229567.1  interleukin-31 receptor subunit alpha isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs at the 5' end and contains an alternate 3' terminal exon compared to variant 1. This results in a shorter isoform (4) with a distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358740, AY499341, AY499342
    Consensus CDS
    CCDS56366.1
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Conserved Domains (3) summary
    smart00060
    Location:434514
    FN3; Fibronectin type 3 domain
    cd00063
    Location:136235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:38132
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. NM_001242639.1NP_001229568.1  interleukin-31 receptor subunit alpha isoform 5

    See identical proteins and their annotated locations for NP_001229568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs at the 5' end and contains an additional internal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (5) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358117, BC110490
    Consensus CDS
    CCDS56367.1
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Related
    ENSP00000427533.1, ENST00000490985.5
    Conserved Domains (2) summary
    smart00060
    Location:311391
    FN3; Fibronectin type 3 domain
    cd00063
    Location:13112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. NM_001297570.2NP_001284499.1  interleukin-31 receptor subunit alpha isoform 6

    See identical proteins and their annotated locations for NP_001284499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 6 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358740, AY499339
    Consensus CDS
    CCDS75244.1
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Related
    ENSP00000380048.2, ENST00000396836.6
    Conserved Domains (2) summary
    cd00063
    Location:155254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:57151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. NM_001297572.2NP_001284501.1  interleukin-31 receptor subunit alpha isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at a downstream start codon and translation termination at an alternate stop codon. The resulting isoform (7) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008914, AK297938, AY358740, BC110490
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Conserved Domains (1) summary
    cd00063
    Location:13112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  7. NM_139017.6NP_620586.3  interleukin-31 receptor subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_620586.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008914, AK297938, AY358117, AY358740, AY499341
    Consensus CDS
    CCDS3970.2
    UniProtKB/Swiss-Prot
    Q8NI17
    UniProtKB/TrEMBL
    B4DNJ2
    Related
    ENSP00000498630.1, ENST00000652347.1
    Conserved Domains (3) summary
    smart00060
    Location:453533
    FN3; Fibronectin type 3 domain
    cd00063
    Location:155254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:57151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55840334..55922854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543142.2XP_011541444.1  interleukin-31 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011541444.1

    UniProtKB/Swiss-Prot
    Q8NI17
    Conserved Domains (3) summary
    smart00060
    Location:421501
    FN3; Fibronectin type 3 domain
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:25119
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011543143.2XP_011541445.1  interleukin-31 receptor subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011541445.1

    UniProtKB/Swiss-Prot
    Q8NI17
    Related
    ENSP00000347047.4, ENST00000354961.8
    Conserved Domains (3) summary
    smart00060
    Location:434514
    FN3; Fibronectin type 3 domain
    cd00063
    Location:136235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:38132
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011543144.2XP_011541446.1  interleukin-31 receptor subunit alpha isoform X3

    See identical proteins and their annotated locations for XP_011541446.1

    UniProtKB/Swiss-Prot
    Q8NI17
    Conserved Domains (2) summary
    smart00060
    Location:311391
    FN3; Fibronectin type 3 domain
    cd00063
    Location:13112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_011543145.2XP_011541447.1  interleukin-31 receptor subunit alpha isoform X4

    Conserved Domains (2) summary
    smart00060
    Location:283363
    FN3; Fibronectin type 3 domain
    cd00063
    Location:284
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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