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IL31RA interleukin 31 receptor A [ Homo sapiens (human) ]

Gene ID: 133396, updated on 5-Aug-2026
Official Symbol
IL31RAprovided by HGNC
Official Full Name
interleukin 31 receptor Aprovided by HGNC
Primary source
HGNC:HGNC:18969
See related
Ensembl:ENSG00000164509 MIM:609510; AllianceGenome:HGNC:18969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17
Summary
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See IL31RA in Genome Data Viewer
Location:
5q11.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55839789..55922850)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (56668079..56751259)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (55147185..55218678)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1-like Neighboring gene DEAD-box helicase 4 Neighboring gene RNA, 5S ribosomal pseudogene 183 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:55098870-55099053 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr5:55198729-55199230 and GRCh37_chr5:55199231-55199730 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:55206646-55207845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:55218660-55219260 Neighboring gene interleukin 6 cytokine family signal transducer Neighboring gene CRISPRi-FlowFISH-validated IL6ST regulatory element GRCh37_chr5:55289559-55291877 Neighboring gene small nucleolar RNA U13 Neighboring gene IL6ST divergent transcript

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis. Ruzicka T, et al. N Engl J Med, 2017 Mar 2. PMID 28249150
  2. Novel systemic drugs in treatment of atopic dermatitis: results from phase II and phase III studies published in 2017/2018. Werfel T. Curr Opin Allergy Clin Immunol, 2018 Oct. PMID 30095475
  3. A novel oncostatin M/interleukin-31 receptor mutation in familial primary localized cutaneous amyloidosis. Adams R, et al. Clin Exp Dermatol, 2020 Mar. PMID 31478212
  4. New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis. Tanaka A, et al. Br J Dermatol, 2009 Dec. PMID 19663869
  5. Interleukin-31: The "itchy" cytokine in inflammation and therapy. Datsi A, et al. Allergy, 2021 Oct. PMID 33629401

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin 31 receptor alpha promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
    Title: Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
  2. IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?
    Title: IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?
  3. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.
    Title: Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.
  4. Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA.
    Title: Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA.
  5. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
    Title: The IL-31/IL-31 receptor axis: general features and role in tumor microenvironment.
  6. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
    Title: The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma.
  7. detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia
    Title: Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis.
  8. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch.
    Title: A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
  9. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells.
    Title: Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation.
  10. IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation
    Title: Interferon-γ induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Amyloidosis, primary localized cutaneous, 2
MedGen: C3151404 OMIM: 613955 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of interleukin 31 receptor A (IL31RA) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
  
enables cytokine binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables transcription coactivator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in homeostatic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in macrophage differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in monocyte differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of macrophage activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interleukin-31 receptor subunit alpha
Names
IL-31 receptor A
IL-31 receptor subunit alpha
IL-31R subunit alpha
class I cytokine receptor
cytokine receptor-like 3
gp130-like monocyte receptor
soluble type I cytokine receptor CRL3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029436.2 RefSeqGene

    Range
    16570..88063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242636.2 → NP_001229565.1  interleukin-31 receptor subunit alpha isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008914
    Consensus CDS
    CCDS75245.1
    UniProtKB/TrEMBL
    A0A494C190
    Related
    ENSP00000297015.4, ENST00000297015.7
    Conserved Domains (3) summary
    smart00060
    Location:434 → 514
    FN3; Fibronectin type 3 domain
    cd00063
    Location:136 → 235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:38 → 132
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001242637.2 → NP_001229566.1  interleukin-31 receptor subunit alpha isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008914, AK297938, AY358740, AY499339
    Consensus CDS
    CCDS56365.1
    UniProtKB/TrEMBL
    A0A494C190
    Related
    ENSP00000351935.5, ENST00000359040.11
    Conserved Domains (3) summary
    smart00060
    Location:453 → 533
    FN3; Fibronectin type 3 domain
    cd00063
    Location:155 → 254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:57 → 151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001242638.2 → NP_001229567.1  interleukin-31 receptor subunit alpha isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229567.1

    Status: REVIEWED

    Source sequence(s)
    AC008914, AK297938, AY358740, AY499341, AY499342
    Consensus CDS
    CCDS56366.1
    UniProtKB/TrEMBL
    A0A494C190
    Related
    ENSP00000347047.4, ENST00000354961.9
    Conserved Domains (3) summary
    smart00060
    Location:434 → 514
    FN3; Fibronectin type 3 domain
    cd00063
    Location:136 → 235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:38 → 132
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_001242639.2 → NP_001229568.1  interleukin-31 receptor subunit alpha isoform 5

    See identical proteins and their annotated locations for NP_001229568.1

    Status: REVIEWED

    Source sequence(s)
    AC008914
    Consensus CDS
    CCDS56367.1
    UniProtKB/TrEMBL
    A0A494C190
    Related
    ENSP00000427533.1, ENST00000490985.5
    Conserved Domains (2) summary
    smart00060
    Location:311 → 391
    FN3; Fibronectin type 3 domain
    cd00063
    Location:13 → 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001297570.3 → NP_001284499.1  interleukin-31 receptor subunit alpha isoform 6

    See identical proteins and their annotated locations for NP_001284499.1

    Status: REVIEWED

    Source sequence(s)
    AC008914
    Consensus CDS
    CCDS75244.1
    Related
    ENSP00000380048.2, ENST00000396836.7
    Conserved Domains (2) summary
    cd00063
    Location:155 → 254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:57 → 151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. NM_139017.7 → NP_620586.3  interleukin-31 receptor subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_620586.3

    Status: REVIEWED

    Source sequence(s)
    AC008914
    Consensus CDS
    CCDS3970.2
    UniProtKB/TrEMBL
    A0A494C190
    Related
    ENSP00000498630.1, ENST00000652347.2
    Conserved Domains (3) summary
    smart00060
    Location:453 → 533
    FN3; Fibronectin type 3 domain
    cd00063
    Location:155 → 254
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59 → 142
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    55839789..55922850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543142.3 → XP_011541444.1  interleukin-31 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011541444.1

    UniProtKB/Swiss-Prot
    A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0
    UniProtKB/TrEMBL
    A0A494C190
    Conserved Domains (3) summary
    smart00060
    Location:421 → 501
    FN3; Fibronectin type 3 domain
    cd00063
    Location:123 → 222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:25 → 119
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_047416701.1 → XP_047272657.1  interleukin-31 receptor subunit alpha isoform X4

  3. XM_047416700.1 → XP_047272656.1  interleukin-31 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A494C190

  4. XM_011543145.2 → XP_011541447.1  interleukin-31 receptor subunit alpha isoform X3

    Conserved Domains (2) summary
    smart00060
    Location:283 → 363
    FN3; Fibronectin type 3 domain
    cd00063
    Location:2 → 84
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    56668079..56751259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351572.1 → XP_054207547.1  interleukin-31 receptor subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0
    UniProtKB/TrEMBL
    A0A494C190

  2. XM_054351575.1 → XP_054207550.1  interleukin-31 receptor subunit alpha isoform X4

  3. XM_054351573.1 → XP_054207548.1  interleukin-31 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A494C190

  4. XM_054351574.1 → XP_054207549.1  interleukin-31 receptor subunit alpha isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001297572.2: Suppressed sequence

    Description
    NM_001297572.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NI17.1 GenPept UniProtKB/Swiss-Prot:Q8NI17

Gene LinkOut

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