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SLC9B2 solute carrier family 9 member B2 [ Homo sapiens (human) ]

Gene ID: 133308, updated on 8-Jul-2021

Summary

Official Symbol
SLC9B2provided by HGNC
Official Full Name
solute carrier family 9 member B2provided by HGNC
Primary source
HGNC:HGNC:25143
See related
Ensembl:ENSG00000164038 MIM:611789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHA2; NHE10; NHEDC2
Summary
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues See more
Orthologs
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Genomic context

See SLC9B2 in Genome Data Viewer
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (103018029..103077319, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (103939186..103998476, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member B1 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 7 Neighboring gene ACTR3B pseudogene 4 Neighboring gene 3-hydroxybutyrate dehydrogenase 2 Neighboring gene centromere protein E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lithium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monovalent cation:proton antiporter activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoclast development IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 9B2
Names
NHE domain-containing protein 2
Na(+)/H(+) exchanger NHA2
Na(+)/H(+) exchanger-like domain-containing protein 2
Na+/H+ exchanger domain containing 2
mitochondrial Na(+)/H(+) exchanger NHA2
mitochondrial sodium/hydrogen exchanger 9B2
mitochondrial sodium/hydrogen exchanger NHA2
sodium/hydrogen exchanger-like domain-containing protein 2
solute carrier family 9 subfamily B member 2
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
solute carrier family 9, subfamily B (cation proton antiporter 2), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300754.2NP_001287683.1  sodium/hydrogen exchanger 9B2 isoform 2

    See identical proteins and their annotated locations for NP_001287683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC097485
    Consensus CDS
    CCDS75174.1
    UniProtKB/TrEMBL
    B7Z488, B7Z676, E9PE63
    Related
    ENSP00000422477.1, ENST00000503230.5
    Conserved Domains (1) summary
    cl01133
    Location:119480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. NM_001300756.2NP_001287685.1  sodium/hydrogen exchanger 9B2 isoform 3

    See identical proteins and their annotated locations for NP_001287685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the central and 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097485
    Consensus CDS
    CCDS75173.1
    UniProtKB/Swiss-Prot
    Q86UD5
    UniProtKB/TrEMBL
    B7Z488, B7Z676
    Related
    ENSP00000425385.1, ENST00000503103.5
    Conserved Domains (1) summary
    cl01133
    Location:119356
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  3. NM_001370199.1NP_001357128.1  sodium/hydrogen exchanger 9B2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC097485
    Conserved Domains (1) summary
    cl01133
    Location:176413
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  4. NM_001370200.1NP_001357129.1  sodium/hydrogen exchanger 9B2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC097485
    Conserved Domains (1) summary
    cl01133
    Location:197475
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  5. NM_001370201.1NP_001357130.1  sodium/hydrogen exchanger 9B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC083826, AC097485
    Conserved Domains (1) summary
    cl01133
    Location:176537
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  6. NM_001370202.1NP_001357131.1  sodium/hydrogen exchanger 9B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC083826, AC097485
    Related
    ENSP00000354574.3, ENST00000362026.7
    Conserved Domains (1) summary
    cl01133
    Location:176537
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  7. NM_001370203.1NP_001357132.1  sodium/hydrogen exchanger 9B2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC097485
    Conserved Domains (1) summary
    cl01133
    Location:119480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  8. NM_001370204.1NP_001357133.1  sodium/hydrogen exchanger 9B2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC083826, AC097485
    Conserved Domains (1) summary
    cl01133
    Location:119480
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  9. NM_001370205.1NP_001357134.1  sodium/hydrogen exchanger 9B2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC083826, AC097485
    Conserved Domains (1) summary
    cl01133
    Location:119356
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  10. NM_001370206.1NP_001357135.1  sodium/hydrogen exchanger 9B2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC083826, AC097485
    Conserved Domains (1) summary
    cl01133
    Location:176413
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  11. NM_001370207.1NP_001357136.1  sodium/hydrogen exchanger 9B2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC097485
    Conserved Domains (1) summary
    cl01133
    Location:176413
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  12. NM_178833.7NP_849155.2  sodium/hydrogen exchanger 9B2 isoform 1

    See identical proteins and their annotated locations for NP_849155.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC097485
    Consensus CDS
    CCDS3662.1
    UniProtKB/Swiss-Prot
    Q86UD5
    UniProtKB/TrEMBL
    A0A024RDJ7, B7Z488
    Related
    ENSP00000378265.3, ENST00000394785.9
    Conserved Domains (1) summary
    cl01133
    Location:176537
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    103018029..103077319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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