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ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 [ Homo sapiens (human) ]

Gene ID: 133121, updated on 1-Aug-2020

Summary

Official Symbol
ENPP6provided by HGNC
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 6provided by HGNC
Primary source
HGNC:HGNC:23409
See related
Ensembl:ENSG00000164303 MIM:616983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPP6
Expression
Biased expression in kidney (RPKM 13.7), ovary (RPKM 7.0) and 5 other tissues See more
Orthologs

Genomic context

See ENPP6 in Genome Data Viewer
Location:
4q35.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (184088706..184217873, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185009859..185139114, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986330 Neighboring gene very low density lipoprotein receptor pseudogene Neighboring gene uncharacterized LOC105377582 Neighboring gene uncharacterized LOC105377584 Neighboring gene ribosomal protein L6 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycerophosphocholine cholinephosphodiesterase activity EXP
Inferred from Experiment
more info
PubMed 
glycerophosphocholine cholinephosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
choline metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
choline metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycerophospholipid catabolic process TAS
Traceable Author Statement
more info
 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glycerophosphocholine cholinephosphodiesterase ENPP6
Names
B830047L21Rik
E-NPP 6
GPC-Cpde
NPP-6
choline-specific glycerophosphodiester phosphodiesterase
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
glycerophosphocholine cholinephosphodiesterase
NP_699174.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153343.4NP_699174.1  glycerophosphocholine cholinephosphodiesterase ENPP6 precursor

    See identical proteins and their annotated locations for NP_699174.1

    Status: VALIDATED

    Source sequence(s)
    AC079080, AC107222, BC035035
    Consensus CDS
    CCDS3834.1
    UniProtKB/Swiss-Prot
    Q6UWR7
    Related
    ENSP00000296741.2, ENST00000296741.7
    Conserved Domains (1) summary
    cd16018
    Location:24397
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    184088706..184217873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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