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PACRGL parkin coregulated like [ Homo sapiens (human) ]

Gene ID: 133015, updated on 21-Dec-2019

Summary

Official Symbol
PACRGLprovided by HGNC
Official Full Name
parkin coregulated likeprovided by HGNC
Primary source
HGNC:HGNC:28442
See related
Ensembl:ENSG00000163138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf28
Expression
Broad expression in brain (RPKM 3.7), testis (RPKM 3.2) and 24 other tissues See more
Orthologs

Genomic context

See PACRGL in Genome Data Viewer
Location:
4p15.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (20696282..20754828)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (20702036..20729980)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 2 Neighboring gene microRNA 218-1 Neighboring gene uncharacterized LOC105374515 Neighboring gene potassium voltage-gated channel interacting protein 4 Neighboring gene uncharacterized LOC105374516 Neighboring gene microRNA 7978

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
PACRG-like protein
Names
PARK2 co-regulated like
PARK2 coregulated like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130727.3NP_001124199.1  PACRG-like protein isoform 2

    See identical proteins and their annotated locations for NP_001124199.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC104065, BU674750, BX104331
    Consensus CDS
    CCDS47034.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000415832.2, ENST00000444671.6
    Conserved Domains (1) summary
    pfam10274
    Location:64120
    ParcG; Parkin co-regulated protein
  2. NM_001258345.3NP_001245274.1  PACRG-like protein isoform 3

    See identical proteins and their annotated locations for NP_001245274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC104065, AK291544, BM763154, BU674750, BX104331, CF121351, DC339941
    Consensus CDS
    CCDS58895.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    UniProtKB/TrEMBL
    A8K679
    Related
    ENSP00000423881.1, ENST00000503585.6
    Conserved Domains (1) summary
    pfam10274
    Location:78245
    ParcG; Parkin co-regulated protein
  3. NM_001258346.3NP_001245275.1  PACRG-like protein isoform 4

    See identical proteins and their annotated locations for NP_001245275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC104065, AK294077, BU674750, BX104331, CF121351
    Consensus CDS
    CCDS58896.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000425461.1, ENST00000502374.5
    Conserved Domains (1) summary
    pfam10274
    Location:70148
    ParcG; Parkin co-regulated protein
  4. NM_001317849.3NP_001304778.1  PACRG-like protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).
    Source sequence(s)
    AC104065, AK291544, BU674750, BX104331, BX344401, CF121351, DC339941
    Consensus CDS
    CCDS82912.1
    UniProtKB/TrEMBL
    A8K679, D6RGK2
    Related
    ENSP00000426286.1, ENST00000513459.5
    Conserved Domains (1) summary
    pfam10274
    Location:70165
    ParcG; Parkin co-regulated protein
  5. NM_001330745.2NP_001317674.1  PACRG-like protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC104065, BC023002, BU674750, BX104331, CF121351, DC339941
    Consensus CDS
    CCDS82912.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    UniProtKB/TrEMBL
    D6RGK2
  6. NM_001330746.2NP_001317675.1  PACRG-like protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).
    Source sequence(s)
    AC104065, AL541740, BC023002, BU674750, BX104331, CF121351, DC339941
    Consensus CDS
    CCDS82912.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    UniProtKB/TrEMBL
    D6RGK2
  7. NM_001330747.2NP_001317676.1  PACRG-like protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).
    Source sequence(s)
    AC104065, AK307092, BC023002, BU674750, BX104331, CF121351, DC339941
    Consensus CDS
    CCDS82912.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    UniProtKB/TrEMBL
    D6RGK2
  8. NM_001330748.2NP_001317677.1  PACRG-like protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).
    Source sequence(s)
    AC104065, AK307786, BC023002, BU674750, BX104331, CF121351
    Consensus CDS
    CCDS82912.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    UniProtKB/TrEMBL
    D6RGK2
    Related
    ENSP00000422394.1, ENST00000513861.5
  9. NM_145048.5NP_659485.1  PACRG-like protein isoform 1

    See identical proteins and their annotated locations for NP_659485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC104065, BC023002, BU674750, BX104331, CF121351, DC339941
    Consensus CDS
    CCDS3427.1
    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000354171.4, ENST00000360916.9
    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein

RNA

  1. NR_047661.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104065, AK307355, BG741791, BU674750, BX104331, CF121351, DC339941
  2. NR_133933.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate 5' and 3' exon structure, and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay.
    Source sequence(s)
    AK098692, AK291544, AW050492, BM763154

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    20696282..20754828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513798.2XP_011512100.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512100.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  2. XM_024453898.1XP_024309666.1  PACRG-like protein isoform X10

    Conserved Domains (1) summary
    pfam10274
    Location:64147
    ParcG; Parkin co-regulated protein
  3. XM_024453896.1XP_024309664.1  PACRG-like protein isoform X9

    Conserved Domains (1) summary
    pfam10274
    Location:70192
    ParcG; Parkin co-regulated protein
  4. XM_017007758.2XP_016863247.1  PACRG-like protein isoform X11

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000424898.1, ENST00000514292.5
    Conserved Domains (1) summary
    pfam10274
    Location:64120
    ParcG; Parkin co-regulated protein
  5. XM_017007747.2XP_016863236.1  PACRG-like protein isoform X5

    Related
    ENSP00000423499.1, ENST00000510051.5
    Conserved Domains (1) summary
    pfam10274
    Location:126266
    ParcG; Parkin co-regulated protein
  6. XM_024453897.1XP_024309665.1  PACRG-like protein isoform X9

    Conserved Domains (1) summary
    pfam10274
    Location:70192
    ParcG; Parkin co-regulated protein
  7. XM_011513784.1XP_011512086.1  PACRG-like protein isoform X1

    See identical proteins and their annotated locations for XP_011512086.1

    Conserved Domains (1) summary
    pfam10274
    Location:126249
    ParcG; Parkin co-regulated protein
  8. XM_017007748.2XP_016863237.1  PACRG-like protein isoform X6

    UniProtKB/Swiss-Prot
    Q8N7B6
    Conserved Domains (1) summary
    pfam10274
    Location:78245
    ParcG; Parkin co-regulated protein
  9. XM_011513788.1XP_011512090.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512090.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  10. XM_017007750.1XP_016863239.1  PACRG-like protein isoform X7

    Conserved Domains (1) summary
    pfam10274
    Location:70148
    ParcG; Parkin co-regulated protein
  11. XM_011513792.1XP_011512094.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512094.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  12. XM_011513794.1XP_011512096.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512096.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  13. XM_011513797.3XP_011512099.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512099.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  14. XM_017007759.2XP_016863248.1  PACRG-like protein isoform X11

    UniProtKB/Swiss-Prot
    Q8N7B6
    Conserved Domains (1) summary
    pfam10274
    Location:64120
    ParcG; Parkin co-regulated protein
  15. XM_017007751.2XP_016863240.1  PACRG-like protein isoform X8

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000295290.8, ENST00000295290.12
    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein
  16. XM_011513805.3XP_011512107.1  PACRG-like protein isoform X8

    See identical proteins and their annotated locations for XP_011512107.1

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000425938.1, ENST00000507634.5
    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein
  17. XM_024453894.1XP_024309662.1  PACRG-like protein isoform X8

    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein
  18. XM_011513786.3XP_011512088.1  PACRG-like protein isoform X3

    See identical proteins and their annotated locations for XP_011512088.1

    Conserved Domains (1) summary
    pfam10274
    Location:126293
    ParcG; Parkin co-regulated protein
  19. XM_011513780.1XP_011512082.1  PACRG-like protein isoform X1

    See identical proteins and their annotated locations for XP_011512082.1

    Conserved Domains (1) summary
    pfam10274
    Location:126249
    ParcG; Parkin co-regulated protein
  20. XM_011513785.1XP_011512087.1  PACRG-like protein isoform X2

    Conserved Domains (1) summary
    pfam10274
    Location:99222
    ParcG; Parkin co-regulated protein
  21. XM_011513796.1XP_011512098.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512098.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  22. XM_011513804.1XP_011512106.1  PACRG-like protein isoform X7

    Conserved Domains (1) summary
    pfam10274
    Location:70148
    ParcG; Parkin co-regulated protein
  23. XM_017007753.2XP_016863242.1  PACRG-like protein isoform X8

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000423536.1, ENST00000506702.5
    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein
  24. XM_017007752.2XP_016863241.1  PACRG-like protein isoform X8

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000423477.1, ENST00000467997.6
    Conserved Domains (1) summary
    pfam10274
    Location:78218
    ParcG; Parkin co-regulated protein
  25. XM_017007749.2XP_016863238.1  PACRG-like protein isoform X6

    UniProtKB/Swiss-Prot
    Q8N7B6
    Related
    ENSP00000423914.2, ENST00000471979.6
    Conserved Domains (1) summary
    pfam10274
    Location:78245
    ParcG; Parkin co-regulated protein
  26. XM_011513787.1XP_011512089.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512089.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  27. XM_011513791.1XP_011512093.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512093.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein
  28. XM_011513795.1XP_011512097.1  PACRG-like protein isoform X4

    See identical proteins and their annotated locations for XP_011512097.1

    Conserved Domains (1) summary
    pfam10274
    Location:78201
    ParcG; Parkin co-regulated protein

RNA

  1. XR_002959710.1 RNA Sequence

  2. XR_925302.2 RNA Sequence

  3. XR_925303.3 RNA Sequence

  4. XR_925305.2 RNA Sequence

  5. XR_925306.2 RNA Sequence

  6. XR_001741142.2 RNA Sequence

  7. XR_001741143.2 RNA Sequence

  8. XR_001741144.2 RNA Sequence

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