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CPEB2 cytoplasmic polyadenylation element binding protein 2 [ Homo sapiens (human) ]

Gene ID: 132864, updated on 13-Mar-2020

Summary

Official Symbol
CPEB2provided by HGNC
Official Full Name
cytoplasmic polyadenylation element binding protein 2provided by HGNC
Primary source
HGNC:HGNC:21745
See related
Ensembl:ENSG00000137449 MIM:610605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPEB-2; CPE-BP2; hCPEB-2
Summary
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 12.0), skin (RPKM 7.9) and 24 other tissues See more
Orthologs

Genomic context

See CPEB2 in Genome Data Viewer
Location:
4p15.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (15002426..15070153)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15004298..15071777)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 504 Neighboring gene uncharacterized LOC105374496 Neighboring gene uncharacterized LOC105374498 Neighboring gene CPEB2 divergent transcript Neighboring gene C1QTNF7 antisense RNA 1 Neighboring gene uncharacterized LOC105374501 Neighboring gene RN7SK pseudogene 170

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119575, MGC119576, MGC119577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to arsenic-containing substance ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytoplasmic translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
messenger ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 2
Names
CPE-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177381.2NP_001170852.1  cytoplasmic polyadenylation element-binding protein 2 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (C) differs at an internal region, compared to isoform D.
    Source sequence(s)
    AC098829, AC105289, BC103939
    Consensus CDS
    CCDS56326.1
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000414270.2, ENST00000442003.6
    Conserved Domains (4) summary
    COG0724
    Location:737912
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:750841
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:858938
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:933994
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  2. NM_001177382.2NP_001170853.1  cytoplasmic polyadenylation element-binding protein 2 isoform D

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) represents the longest transcript and encodes the longest isoform (D).
    Source sequence(s)
    AC098829, AC105289, BC103942
    Consensus CDS
    CCDS56325.1
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000443985.1, ENST00000538197.6
    Conserved Domains (4) summary
    COG0724
    Location:764939
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:777868
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:885965
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9601021
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  3. NM_001177383.2NP_001170854.1  cytoplasmic polyadenylation element-binding protein 2 isoform E

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (E) lacks an internal segment, compared to isoform D.
    Source sequence(s)
    AC098829, AC105289, BC103941
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000371832.4, ENST00000382395.8
    Conserved Domains (4) summary
    COG0724
    Location:734909
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:747838
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:855935
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:930991
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  4. NM_001177384.2NP_001170855.1  cytoplasmic polyadenylation element-binding protein 2 isoform F

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the central coding region, compared to variant D. The resulting isoform (F) differs at two internal regions, compared to isoform D.
    Source sequence(s)
    AC098829, AC105289, BC105925
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000371838.4, ENST00000382401.8
    Conserved Domains (4) summary
    COG0724
    Location:729904
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:742833
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:850930
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:925986
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  5. NM_182485.3NP_872291.2  cytoplasmic polyadenylation element-binding protein 2 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) lacks two alternate in-frame exons in the central coding region, compared to variant D. The resulting isoform (B) lacks two internal segments, compared to isoform D.
    Source sequence(s)
    AC098829, AC105289, AY247744
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000424084.2, ENST00000507071.6
    Conserved Domains (4) summary
    COG0724
    Location:756931
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:769860
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:877957
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9521013
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  6. NM_182646.3NP_872587.2  cytoplasmic polyadenylation element-binding protein 2 isoform A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks an alternate in-frame exon in the central coding region, compared to variant D. The resulting isoform (A) lacks an internal segment, compared to isoform D.
    Source sequence(s)
    AC098829, AC105289, AY255519
    UniProtKB/Swiss-Prot
    Q7Z5Q1
    Related
    ENSP00000334058.4, ENST00000345451.8
    Conserved Domains (4) summary
    COG0724
    Location:726901
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:739830
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:847927
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:922983
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    15002426..15070153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513779.2XP_011512081.1  cytoplasmic polyadenylation element-binding protein 2 isoform X4

  2. XM_011513778.3XP_011512080.1  cytoplasmic polyadenylation element-binding protein 2 isoform X3

  3. XM_005248135.3XP_005248192.2  cytoplasmic polyadenylation element-binding protein 2 isoform X1

    Conserved Domains (4) summary
    COG0724
    Location:767942
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:780871
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:888968
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9631024
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  4. XM_011513777.3XP_011512079.1  cytoplasmic polyadenylation element-binding protein 2 isoform X2

    Conserved Domains (4) summary
    COG0724
    Location:759934
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:772863
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:880960
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:9551016
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  5. XM_017007734.2XP_016863223.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

    Conserved Domains (3) summary
    cd12724
    Location:206297
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:314394
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:389450
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
  6. XM_017007733.1XP_016863222.1  cytoplasmic polyadenylation element-binding protein 2 isoform X5

    Conserved Domains (3) summary
    cd12724
    Location:206297
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:314394
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:389450
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171799.1 Reference GRCh38.p13 PATCHES

    Range
    74375..89176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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