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SPATA4 spermatogenesis associated 4 [ Homo sapiens (human) ]

Gene ID: 132851, updated on 30-Jan-2020

Summary

Official Symbol
SPATA4provided by HGNC
Official Full Name
spermatogenesis associated 4provided by HGNC
Primary source
HGNC:HGNC:17333
See related
Ensembl:ENSG00000150628 MIM:609879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP178; SPEF1B; TSARG2; CFAP178
Expression
Restricted expression toward testis (RPKM 71.0) See more
Orthologs

Genomic context

See SPATA4 in Genome Data Viewer
Location:
4q34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (176184579..176195585, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177105725..177116822, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 2 pseudogene 4 Neighboring gene WD repeat domain 17 Neighboring gene ankyrin repeat and SOCS box containing 5 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of spermatogenesis associated 4 (SPATA4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
spermatogenesis-associated protein 4
Names
testis and spermatogenesis cell related protein 2
testis spermatocyte apoptosis-related gene 2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144644.4NP_653245.2  spermatogenesis-associated protein 4

    See identical proteins and their annotated locations for NP_653245.2

    Status: VALIDATED

    Source sequence(s)
    AY040204
    Consensus CDS
    CCDS3826.1
    UniProtKB/Swiss-Prot
    Q8NEY3
    Related
    ENSP00000280191.2, ENST00000280191.7
    Conserved Domains (1) summary
    pfam06294
    Location:56145
    CH_2; CH-like domain in sperm protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    176184579..176195585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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