Format

Send to:

Choose Destination

TMPRSS11B transmembrane serine protease 11B [ Homo sapiens (human) ]

Gene ID: 132724, updated on 11-Jun-2021

Summary

Official Symbol
TMPRSS11Bprovided by HGNC
Official Full Name
transmembrane serine protease 11Bprovided by HGNC
Primary source
HGNC:HGNC:25398
See related
Ensembl:ENSG00000185873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HATL5
Expression
Restricted expression toward esophagus (RPKM 184.2) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMPRSS11B in Genome Data Viewer
Location:
4q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (68226653..68245694, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69092371..69111412, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 11F Neighboring gene solute carrier family 47 member 2 pseudogene Neighboring gene TMPRSS11B N-terminal like, pseudogene Neighboring gene ferritin light chain pseudogene 10 Neighboring gene UDP glucuronosyltransferase family 2 member B11 pseudogene Neighboring gene apolipoprotein O pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686L1818

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protease serine 11B
Names
airway trypsin-like protease 5
transmembrane protease, serine 11B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182502.3NP_872308.2  transmembrane protease serine 11B

    See identical proteins and their annotated locations for NP_872308.2

    Status: VALIDATED

    Source sequence(s)
    AC098799, AK290904
    Consensus CDS
    CCDS3521.1
    UniProtKB/Swiss-Prot
    Q86T26
    Related
    ENSP00000330475.5, ENST00000332644.6
    Conserved Domains (3) summary
    smart00020
    Location:184410
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:185413
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:45143
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    68226653..68245694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531608.2XP_011529910.1  transmembrane protease serine 11B isoform X1

    See identical proteins and their annotated locations for XP_011529910.1

    UniProtKB/Swiss-Prot
    Q86T26
    Conserved Domains (3) summary
    smart00020
    Location:184410
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:185413
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:45143
    SEA; SEA domain
  2. XM_011531609.1XP_011529911.1  transmembrane protease serine 11B isoform X2

    Conserved Domains (2) summary
    pfam01390
    Location:45143
    SEA; SEA domain
    cl21584
    Location:185227
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Support Center