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ZFP42 ZFP42 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 132625, updated on 23-Nov-2021

Summary

Official Symbol
ZFP42provided by HGNC
Official Full Name
ZFP42 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:30949
See related
Ensembl:ENSG00000179059 MIM:614572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REX1; REX-1; ZNF754; zfp-42
Expression
Biased expression in testis (RPKM 1.0), placenta (RPKM 0.5) and 1 other tissue See more
Orthologs
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Genomic context

See ZFP42 in Genome Data Viewer
Location:
4q35.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (187994044..188005046)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (188916925..188926200)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 20 pseudogene 3 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 7889 Neighboring gene uncharacterized LOC107986337 Neighboring gene tripartite motif family like 2 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene FAU pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in female gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in meiotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 42 homolog
Names
REX1 transcription factor
reduced expression protein 1
zinc finger protein 754

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304358.2NP_001291287.1  zinc finger protein 42 homolog

    See identical proteins and their annotated locations for NP_001291287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA641545, AC108073, AK056719
    Consensus CDS
    CCDS3849.1
    UniProtKB/Swiss-Prot
    Q96MM3
    Related
    ENSP00000424662.1, ENST00000509524.5
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain
  2. NM_174900.5NP_777560.2  zinc finger protein 42 homolog

    See identical proteins and their annotated locations for NP_777560.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA641545, AC108073, AY429593
    Consensus CDS
    CCDS3849.1
    UniProtKB/Swiss-Prot
    Q96MM3
    Related
    ENSP00000317686.4, ENST00000326866.5
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    187994044..188005046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531607.2XP_011529909.1  zinc finger protein 42 homolog isoform X1

    See identical proteins and their annotated locations for XP_011529909.1

    UniProtKB/Swiss-Prot
    Q96MM3
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011531604.2XP_011529906.1  zinc finger protein 42 homolog isoform X1

    See identical proteins and their annotated locations for XP_011529906.1

    UniProtKB/Swiss-Prot
    Q96MM3
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011531606.1XP_011529908.1  zinc finger protein 42 homolog isoform X1

    See identical proteins and their annotated locations for XP_011529908.1

    UniProtKB/Swiss-Prot
    Q96MM3
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011531605.1XP_011529907.1  zinc finger protein 42 homolog isoform X1

    See identical proteins and their annotated locations for XP_011529907.1

    UniProtKB/Swiss-Prot
    Q96MM3
    Conserved Domains (3) summary
    COG5048
    Location:214307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:219239
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232257
    zf-H2C2_2; Zinc-finger double domain
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