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PABPC4L poly(A) binding protein cytoplasmic 4 like [ Homo sapiens (human) ]

Gene ID: 132430, updated on 6-Nov-2022

Summary

Official Symbol
PABPC4Lprovided by HGNC
Official Full Name
poly(A) binding protein cytoplasmic 4 likeprovided by HGNC
Primary source
HGNC:HGNC:31955
See related
Ensembl:ENSG00000254535 AllianceGenome:HGNC:31955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PABPC4L in Genome Data Viewer
Location:
4q28.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (133948459..134201901, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (137518798..137524254, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (135117488..135122944, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900863 Neighboring gene Sharpr-MPRA regulatory region 13606 Neighboring gene Sharpr-MPRA regulatory region 7344 Neighboring gene pescadillo ribosomal biogenesis factor 1 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 2462 Neighboring gene Sharpr-MPRA regulatory region 8780

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686J06116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein 4-like
Names
PABP-4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114734.2NP_001108206.3  polyadenylate-binding protein 4-like

    Status: VALIDATED

    Source sequence(s)
    AC015631, BX648831, DR005318
    Consensus CDS
    CCDS47135.1
    UniProtKB/Swiss-Prot
    P0CB38
    Related
    ENSP00000463233.1, ENST00000421491.4
    Conserved Domains (1) summary
    cl25887
    Location:10369
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_001363585.1NP_001350514.1  polyadenylate-binding protein 4-like

    Status: VALIDATED

    Source sequence(s)
    AC015631
    Consensus CDS
    CCDS47135.1
    UniProtKB/Swiss-Prot
    P0CB38
    Conserved Domains (1) summary
    cl25887
    Location:10369
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    133948459..134201901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449600.1XP_047305556.1  polyadenylate-binding protein 4-like isoform X1

RNA

  1. XR_001741133.2 RNA Sequence

  2. XR_007096357.1 RNA Sequence

  3. XR_001741139.2 RNA Sequence

  4. XR_001741135.2 RNA Sequence

  5. XR_001741134.2 RNA Sequence

  6. XR_007096356.1 RNA Sequence

  7. XR_001741136.2 RNA Sequence

  8. XR_001741138.2 RNA Sequence

  9. XR_001741137.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    137518798..137524254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)