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H1-8 H1.8 linker histone [ Homo sapiens (human) ]

Gene ID: 132243, updated on 5-Aug-2022

Summary

Official Symbol
H1-8provided by HGNC
Official Full Name
H1.8 linker histoneprovided by HGNC
Primary source
HGNC:HGNC:18463
See related
Ensembl:ENSG00000178804 AllianceGenome:HGNC:18463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1.8; H1oo; osH1; H1FOO
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See H1-8 in Genome Data Viewer
Location:
3q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129543175..129551467)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132287585..132295894)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129262018..129270310)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene rhodopsin enhancer region Neighboring gene rhodopsin Neighboring gene Sharpr-MPRA regulatory region 2951 Neighboring gene Sharpr-MPRA regulatory region 1469 Neighboring gene plexin D1 Neighboring gene RNA, 7SL, cytoplasmic 752, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural constituent of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epigenetic regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
NOT located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
histone H1.8
Names
H1 histone family member O oocyte specific
histone H1oo
oocyte-specific histone H1
oocyte-specific linker histone H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308262.2NP_001295191.1  histone H1.8 isoform 2

    See identical proteins and their annotated locations for NP_001295191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons and contains an alternate 5' terminal exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC047943, BM564157
    Consensus CDS
    CCDS77815.1
    UniProtKB/Swiss-Prot
    Q8IZA3
    Related
    ENSP00000422964.1, ENST00000503977.1
    Conserved Domains (1) summary
    PRK12373
    Location:793
    PRK12373; NADH dehydrogenase subunit E; Provisional
  2. NM_153833.3NP_722575.1  histone H1.8 isoform 1

    See identical proteins and their annotated locations for NP_722575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC080007
    Consensus CDS
    CCDS3064.1
    UniProtKB/Swiss-Prot
    Q86WT7, Q8IZA3
    Related
    ENSP00000319799.2, ENST00000324382.7
    Conserved Domains (1) summary
    cd00073
    Location:49139
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    129543175..129551467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005733.2XP_016861222.1  histone H1.8 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZA3
    Conserved Domains (1) summary
    PRK12373
    Location:793
    PRK12373; NADH dehydrogenase subunit E; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    132287585..132295894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)