Format

Send to:

Choose Destination

LSMEM2 leucine rich single-pass membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 132228, updated on 23-Nov-2021

Summary

Official Symbol
LSMEM2provided by HGNC
Official Full Name
leucine rich single-pass membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:26781
See related
Ensembl:ENSG00000179564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf45
Expression
Ubiquitous expression in heart (RPKM 6.3), prostate (RPKM 1.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LSMEM2 in Genome Data Viewer
Location:
3p21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50277907..50288116)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50316518..50325545)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SEMA3B antisense RNA 1 (head to head) Neighboring gene semaphorin 3B Neighboring gene microRNA 6872 Neighboring gene interferon related developmental regulator 2 Neighboring gene hyaluronidase 3 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich single-pass membrane protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304385.2NP_001291314.1  leucine-rich single-pass membrane protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC028000, DA830939, U90094
    UniProtKB/Swiss-Prot
    Q8N112
    Conserved Domains (1) summary
    pfam15833
    Location:13161
    DUF4714; Domain of unknown function (DUF4714)
  2. NM_153215.3NP_694947.1  leucine-rich single-pass membrane protein 2 isoform 1

    See identical proteins and their annotated locations for NP_694947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC028000, U90094
    Consensus CDS
    CCDS2814.1
    UniProtKB/Swiss-Prot
    Q8N112
    Related
    ENSP00000315081.3, ENST00000316436.4
    Conserved Domains (1) summary
    pfam15833
    Location:14162
    DUF4714; Domain of unknown function (DUF4714)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50277907..50288116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533370.3XP_011531672.1  leucine-rich single-pass membrane protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011531672.1

    Conserved Domains (1) summary
    pfam15833
    Location:1138
    DUF4714; Domain of unknown function (DUF4714)
  2. XM_006712980.4XP_006713043.1  leucine-rich single-pass membrane protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15833
    Location:29170
    DUF4714; Domain of unknown function (DUF4714)
  3. XM_006712979.4XP_006713042.1  leucine-rich single-pass membrane protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15833
    Location:29171
    DUF4714; Domain of unknown function (DUF4714)
  4. XM_024453354.1XP_024309122.1  leucine-rich single-pass membrane protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15833
    Location:1138
    DUF4714; Domain of unknown function (DUF4714)
Support Center