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C53A5.17 tRNA (guanine(37)-N(1))-methyltransferase [ Caenorhabditis elegans ]

Gene ID: 13216595, updated on 23-Apr-2026
Official Symbol
C53A5.17
Official Full Name
tRNA (guanine(37)-N(1))-methyltransferase
Primary source
WormBase:WBGene00194707
Locus tag
CELE_C53A5.17
See related
AllianceGenome:WB:WBGene00194707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in mitochondrion and nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
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See C53A5.17 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (14519371..14521100, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Serpentine receptor class gamma Neighboring gene ATP synthase subunit s, mitochondrial Neighboring gene Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein Neighboring gene Venom protein

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tRNA (guanine(37)-N(1))-methyltransferase
NP_001256592.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14519371..14521100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269663.2 → NP_001256592.1  tRNA (guanine(37)-N(1))-methyltransferase

    See identical proteins and their annotated locations for NP_001256592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WHT1
    Conserved Domains (2) summary
    pfam02475
    Location:144 → 363
    Met_10; Met-10+ like-protein
    cl17173
    Location:268 → 311
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8WHT1.1

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