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Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 [ Mus musculus (house mouse) ]

Gene ID: 13204, updated on 26-Sep-2022

Summary

Official Symbol
Dhx15provided by MGI
Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 15provided by MGI
Primary source
MGI:MGI:1099786
See related
Ensembl:ENSMUSG00000029169 AllianceGenome:MGI:1099786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBP1; HRH2; DEAH9; Ddx15; mDEAH9
Summary
Predicted to enable double-stranded RNA binding activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 55.8), CNS E14 (RPKM 38.2) and 25 other tissues See more
Orthologs
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Genomic context

See Dhx15 in Genome Data Viewer
Location:
5; 5 C1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52307545..52347888, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52150203..52190546, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Neighboring gene predicted gene 42614 Neighboring gene RIKEN cDNA 9230114K14 gene Neighboring gene predicted gene, 40302 Neighboring gene microRNA 6417 Neighboring gene RIKEN cDNA C130083M11 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117685

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type post-mRNA release spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX15
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A)
DEAH box protein 15
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
NP_001036085.1
NP_031865.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042620.2NP_001036085.1  ATP-dependent RNA helicase DHX15 isoform 1

    See identical proteins and their annotated locations for NP_001036085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 3' terminal exon, resulting in a different 3' UTR and 3' coding region, compared to variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK043111, AK149869, BY285872
    Consensus CDS
    CCDS80280.1
    UniProtKB/TrEMBL
    Q3UDX4, Q497W9
    Related
    ENSMUSP00000143069.2, ENSMUST00000199321.5
    Conserved Domains (5) summary
    smart00490
    Location:382475
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:149322
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:545628
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:154295
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:662701
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. NM_007839.3NP_031865.2  ATP-dependent RNA helicase DHX15 isoform 2

    See identical proteins and their annotated locations for NP_031865.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK145983, AK149869, BP767627, BY285872
    Consensus CDS
    CCDS39085.1
    UniProtKB/Swiss-Prot
    O35286, Q99L91
    UniProtKB/TrEMBL
    A0A6P5PJR6, Q3UDX4, Q3UKJ6
    Related
    ENSMUSP00000031061.8, ENSMUST00000031061.12
    Conserved Domains (1) summary
    COG1643
    Location:124763
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_104311.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK145983, AK168835, AK169174, BP767627, BY285872

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52307545..52347888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)