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Ddt D-dopachrome tautomerase [ Mus musculus (house mouse) ]

Gene ID: 13202, updated on 8-Feb-2024

Summary

Official Symbol
Ddtprovided by MGI
Official Full Name
D-dopachrome tautomeraseprovided by MGI
Primary source
MGI:MGI:1298381
See related
Ensembl:ENSMUSG00000001666 AllianceGenome:MGI:1298381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protease binding activity. Involved in positive regulation of inflammatory response. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to several human genes including DDT (D-dopachrome tautomerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 301.3), liver E18 (RPKM 164.9) and 24 other tissues See more
Orthologs
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Genomic context

See Ddt in Genome Data Viewer
Location:
10 C1; 10 38.58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75607067..75609208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75771233..75773374, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene calcineurin binding protein 1 Neighboring gene predicted gene, 40696 Neighboring gene STARR-positive B cell enhancer mm9_chr10:75226990-75227291 Neighboring gene STARR-positive B cell enhancer ABC_E9346 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene glutathione S-transferase, theta 3 Neighboring gene glutathione S-transferase, theta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-dopachrome decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables phenylpyruvate tautomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phenylpyruvate tautomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
D-dopachrome decarboxylase
NP_034157.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010027.1NP_034157.1  D-dopachrome decarboxylase

    See identical proteins and their annotated locations for NP_034157.1

    Status: PROVISIONAL

    Source sequence(s)
    AF012431
    Consensus CDS
    CCDS23930.1
    UniProtKB/Swiss-Prot
    O35215
    UniProtKB/TrEMBL
    Q3UNI8
    Related
    ENSMUSP00000001716.8, ENSMUST00000001716.8
    Conserved Domains (1) summary
    pfam01187
    Location:2116
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75607067..75609208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)